干旱区生态环境知识资源中心(Arid): 在线固相萃取-超高效液相色谱/串联质谱法测定饮用水中8种精神类药物

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	在线固相萃取-超高效液相色谱/串联质谱法测定饮用水中8种精神类药物
其他题名	Determination of Psychotropic Pharmaceuticals in Drinking Water by Online Solid Phase Extraction Coupled with Ultra Performance Liquid Chromatography/Tandem Mass Spectrometry
	王珮玥; 梁娜娜; 冯鑫; 韩深; 崔风云; 齐鹤鸣
来源期刊	分析科学学报
ISSN	1006-6144
出版年	2018
卷号	34 期号:6 页码:777-782
中文摘要	采用在线固相萃取-超高效液相色谱/串联质谱技术,建立了饮用水中奥卡西平、卡马西平、阿米替林、舍曲林、帕罗西汀、阿利马嗪、氯米帕明和氟西汀8种精神类药物的检测方法。样品经微孔滤膜过滤,用甲酸调节至pH=3.0,直接进入在线固相萃取-超高效液相色谱/串联质谱仪进行分析。实验确定样品以OasisHLB柱净化富集,采用ACQUITY HSS T3色谱柱分离,流动相为乙腈和0.5%(体积分数)甲酸水溶液,以电喷雾正离子多反应监测模式(MRM)进行定性定量分析。方法的定量限(LOQ)为0.1 ng/L,平均回收率为68.9%~105.8%,相对标准偏差为3.6%~13.6%(n=6)。将建立的方法应用于北京市部分饮用水源地水样的分析,检测出2种精神类药物。
英文摘要	An online solid phase extraction-ultra performance liquid chromatography/tandem mass spectrometry(SPE-UPLC-MS/MS) method was established to simultaneously determine eight psychotropic pharmaceuticals(Oxcarbazepine,Carbamazepine,Amitriptyline,Sertraline,Paroxetine,Alimemazine,Clomipramine and Fluoxetine)in drinking water.The samples were filtered by millipore filter membrane,adjusted to acidic and then directly injected into online SPE-UPLC-MS/MS.Oasis HLB carriage was used as an online SPE cartridge to purify and enrich the sample.The analytes were separated using an ACQUITY HSS T3 column and a binary mobile phase consisting of acetonitrile and water with 0.5%formic acid under the gradient elution.The eight psychotropic pharmacenticals were identified and quantified by positive electrospray ionization tandem mass spectrometry in multiple reaction monitoring(MRM)mode.The limits of quantification were 0.1 ng/L.The average recoveries in the matrix were ranging from 68.9%to 105.8% with the relative standard deviations(RSDs)of 3.6%-13.6%(n=6).The developed method was applied to analyze the water samples from Beijing.The results showed two psychotropic pharmacenticals were detected in samples.
中文关键词	饮用水 ; 精神类药物 ; 在线固相萃取 ; 超高效液相色谱/串联质谱法
英文关键词	Drinking water Psychotropic pharmaceuticals Online SPE UPLC-MS/MS
语种	中文
国家	中国
收录类别	CSCD
WOS类目	CHEMISTRY ANALYTICAL
WOS研究方向	Chemistry
CSCD记录号	CSCD:6392698
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/237512
作者单位	北京出入境检验检疫局检验检疫技术中心, 北京 100026, 中国
推荐引用方式 GB/T 7714	王珮玥,梁娜娜,冯鑫,等. 在线固相萃取-超高效液相色谱/串联质谱法测定饮用水中8种精神类药物[J],2018,34(6):777-782.
APA	王珮玥,梁娜娜,冯鑫,韩深,崔风云,&齐鹤鸣.(2018).在线固相萃取-超高效液相色谱/串联质谱法测定饮用水中8种精神类药物.分析科学学报,34(6),777-782.
MLA	王珮玥,et al."在线固相萃取-超高效液相色谱/串联质谱法测定饮用水中8种精神类药物".分析科学学报 34.6(2018):777-782.