干旱区生态环境知识资源中心(Arid): 超高效液相色谱-三重四极杆质谱测定沉积物中6种对羟基苯甲酸酯及其代谢产物

Arid

	超高效液相色谱-三重四极杆质谱测定沉积物中6种对羟基苯甲酸酯及其代谢产物
其他题名	Determination of Paraben and Its Metabolite in Sediments by Ultra Performance Liquid Chromatography-Triple Quadrupole Tandem Mass Spectrometry
	赵佳慧; 冯精兰; 席楠楠; 孙剑辉
来源期刊	分析化学
ISSN	0253-3820
出版年	2018
卷号	46 期号:2 页码:260-264
中文摘要	建立了一种测定沉积物中6种对羟基苯甲酸酯类化合物及其代谢产物对羟基苯甲酸的定量分析方法。样品用甲醇-水(5∶ 3,V/V)混合液进行两次提取,经Oasis MCX固相萃取柱净化,采用UPLC HSS T3色谱柱分离,以甲醇-0.1%(V/V)甲酸溶液为流动相进行梯度洗脱,在多反应监测(MRM)模式下进行定性分析,内标法进行定量分析。结果表明,7种目标物质在0.1~ 500.0 mug /L范围内有良好的线性关系(r≥0.9995),方法定量限为0.75~ 1.23 ng /g,回收率为65.5%~ 88.3%,相对标准偏差为7.4%~ 13.6%。本方法前处理简单,灵敏度高,选择性好,可用于沉积物中对羟基苯甲酸酯类化合物的测定。
英文摘要	A new method for simultaneous determination of six benzoic acid esters and their metabolite phydroxybenzoic acid (p-HB) in sediments was developed. The samples were extracted with methanol and water,and then the extraction was purified by Oasis MCX solid phase column. The separation of targets was conducted by passing through a UPLC HSS T3 column with a methanol-0.1% acid aqueous solution as the mobile phase under gradient elution. The qualitative analysis of the analytes was measured by Ultra performance liquid chromatography-Triple quadrupole tandem mass under multiple reaction monitoring mode (MRM) and the internal standard method was applied for quantitative analysis. The results indicated that seven target substances had a good linear relationship in the range of 0.1 - 500 mug /L with correlation coefficients above 0.9995 and the detection limits of 0.75-1.23 ng /g. The recoveries ranged from 65.5% to 88.3% and the relative standard deviation was 7.4%-13.6%. This method was suitable for the measurement of benzoic acid esters with the advantages such as simple processing,good selectivity and high sensitivity.
中文关键词	超高效液相色谱-三重四极杆质谱 ; 对羟基苯甲酸酯 ; 沉积物
英文关键词	Ultra performance liquid chromatography-triple quadrupole tandem mass spectrometry Benzoic acid esters Sediment
语种	中文
国家	中国
收录类别	CSCD
WOS类目	CHEMISTRY ANALYTICAL
WOS研究方向	Chemistry
CSCD记录号	CSCD:6186783
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/237509
作者单位	河南师范大学化学与环境科学学院, 河南省环境污染控制重点实验室, 新乡, 河南 453007, 中国
推荐引用方式 GB/T 7714	赵佳慧,冯精兰,席楠楠,等. 超高效液相色谱-三重四极杆质谱测定沉积物中6种对羟基苯甲酸酯及其代谢产物[J],2018,46(2):260-264.
APA	赵佳慧,冯精兰,席楠楠,&孙剑辉.(2018).超高效液相色谱-三重四极杆质谱测定沉积物中6种对羟基苯甲酸酯及其代谢产物.分析化学,46(2),260-264.
MLA	赵佳慧,et al."超高效液相色谱-三重四极杆质谱测定沉积物中6种对羟基苯甲酸酯及其代谢产物".分析化学 46.2(2018):260-264.