干旱区生态环境知识资源中心(Arid): 污水中常见违禁药物分析方法优化及验证

Arid

	污水中常见违禁药物分析方法优化及验证
其他题名	Optimization and Validation of the Analytical Method to Detect Common Illicit Drugs in Wastewater
	高婷婷 1; 杜鹏 1; 徐泽琼 1; 杨军 2; 张华方 2; 李喜青 1
来源期刊	环境科学
ISSN	0250-3301
出版年	2017
卷号	38 期号:1 页码:201-211
中文摘要	违禁药物作为一种新型污染物得到了环境科学界的广泛关注. 本文根据国内外已有研究,比较了污水样的前处理条件如SPE柱和水样pH值、冲洗、酸化及复溶过程. 结果表明,对实际污水样的前处理应将样品pH值调为2,选用Oasis MCX柱,无需除杂质的冲洗和氮吹过程的酸化步骤,因两种上机测定方法HILIC-UPLC-MS/MS和C18-UPLC-MS/MS不同而分别选择200 muL乙腈和100 muL乙腈+100 muL 5 mmol·L~(-1)乙酸铵复溶. 通过比较HILIC法和C18法的保留时间及检出限、定量限、回收率和基质效应等方法评价指标,确定污水样的测定应选用C18-UPLC-MS/MS. 最后,将优化后的测定方法用于分析北京市12家污水处理厂的进、出水样,验证了方法的可靠性,为违禁药物的污水流行病学研究和环境风险评价奠定了基础.
英文摘要	Illicit drugs have been recognized as a group of emerging pollutants. Based on previous research, procedures to pre-treat wastewater including SPE column, pH of water samples, and processes of washing, acidifying and re-dissolving were compared. It was found that the best recovery was achieved when wastewater was adjusted to pH=2 and Oasis MCX column was used. It was not necessary to flush the loaded column or to acidify the eluate prior to evaporation using nitrogen steam. After evaporation, it is recommended to redissolve the evaporated samples using 200 muL acetonitrile and 100 muL acetonitrile+100 muL 5 mmol·L~(-1) ammonium acetate in Milli-Q water for HILIC-UPLC-MS/MS and C18-UPLC-MS/MS, respectively. After comparing retention times, limit of detection, limit of quantification, recoveries, and matrix effects of HILIC and C18 methods, C18-UPLC-MS/MS was chosen. Influent and effluent samples from 12 wastewater treatment plants in Beijing were analyzed using the optimized method for validation. The validated methods set a firm foundation to apply the sewage-based epidemiology to monitor illicit drug abuse in China.
中文关键词	违禁药物 ; 污水 ; 固相萃取 ; 超高效液相色谱-串联质谱 ; 回收率
英文关键词	illicit drugs wastewater SPE UPLC-MS/MS recovery
语种	中文
国家	中国
收录类别	CSCD
WOS类目	ENVIRONMENTAL SCIENCES
WOS研究方向	Environmental Sciences & Ecology
CSCD记录号	CSCD:5896383
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/236185
作者单位	1.北京大学城市与环境学院,地表过程与分析实验室, 北京 100871, 中国; 2.北京市城市排水监测总站有限公司, 北京 100012, 中国
推荐引用方式 GB/T 7714	高婷婷,杜鹏,徐泽琼,等. 污水中常见违禁药物分析方法优化及验证[J],2017,38(1):201-211.
APA	高婷婷,杜鹏,徐泽琼,杨军,张华方,&李喜青.(2017).污水中常见违禁药物分析方法优化及验证.环境科学,38(1),201-211.
MLA	高婷婷,et al."污水中常见违禁药物分析方法优化及验证".环境科学 38.1(2017):201-211.