干旱区生态环境知识资源中心(Arid): 乳腺癌原发灶和淋巴结转移灶HER2基因状态对比分析

Arid

	乳腺癌原发灶和淋巴结转移灶HER2基因状态对比分析
其他题名	Comparison of HER2 gene status between primary breast cancer and synchronous axillary lymph node metastasis
	刘媛媛; 武莎斐; 梁智勇; 曾瑄
来源期刊	中华病理学杂志
ISSN	0529-5807
出版年	2016
卷号	45 期号:6 页码:392-396
中文摘要	目的探讨乳腺癌原发灶和淋巴结转移灶HER2基因状态及其差异。方法收集2012年5月至2015年6月间浸润性乳腺癌石蜡标本共150例,其中包括原发灶HER2基因扩增、无扩增及不确定3种基因状态各50例,且均有同侧腋窝淋巴结标本。以荧光原位杂交法(FISH)检测腋窝淋巴结转移灶的HER2基因状态,分析其原发灶与淋巴结转移灶之间HER2基因状态不一致性的发生率。结果本组乳腺癌原发灶与其同侧腋窝淋巴结转移灶的HER2基因状态不一致率为20.7% (31/150)。原发灶HER2阳性的50例标本中,其淋巴结HER2阳性44例、不确定3例、阴性3例;原发灶HER2阴性的50例标本中,其淋巴结HER2阴性47例、不确定3例;原发灶HER2基因状态不确定的50例标本中,其淋巴结HER2阳性4例、阴性18例、不确定28例。HER2状态不确定组患者转移灶的HER2基因状态与原发灶HER2基因状态的差异,明显高于前两组,差异具有统计学意义(P<0.05)。结论乳腺癌原发灶与淋巴结转移灶之间的HER2基因状态存在一定的差异,对于淋巴结阳性的乳腺癌来说,必要时可再次检测同侧腋窝淋巴结,或原发灶与转移灶同时检测。对于原发灶HER2基因状态不确定的浸润性乳腺癌来说,检测腋窝淋巴结HER2基因状态,对于临床上抗HER2治疗方案的选择更有参考意义。
英文摘要	Objective To investigate the discordant rate of HER2 gene status between primary breast cancer and synchronous axillary lymph node metastasis. Methods One hundred and fifty cases of primary breast cancer with corresponding synchronous lymph node metastases were collected, including 50 cases of HER2 FISH positive, 50 cases of HER2 FISH negative and 50 cases of HER2 FISH equivocal primary tumors, at Peking Union Medical College Hospital between May 2012 and June 2015. The HER2 gene status in lymph node metastatic tumors was analyzed by FISH,and the discordance of HER2 gene status was identified between primary and metastatic tumors. Results The incidence of discordant HER2 gene status between primary breast cancer and synchronous lymph node metastasis was 20.67% (31/150). Forty- four FISH positive, 3 FISH equivocal and 3 FISH negative cases were found in the first group of 50 patients with HER2 positive results in primary tumor. Forty seven FISH negative, 3 FISH equivocal cases were discovered in the second group of 50 patients with HER2 negative results in primary tumor. Four FISH positive, 18 FISH negative and 28 equivocal oases were observed in the third group of 50 patients with HER2 equivocal results in primary tumor. The discordance of HER2 gene status between primary tumor and lymph node metastasis in the third group of patients was significantly higher than the other two groups (P < 0.05). Conclusions Significant discordance of HER2 gene status between the primary and lymph node metastatic tumors exists. Patients with lymph node metastasis, simultaneous testing of HER2 status may be performed in both primary breast tumor and its lymph node metastasis. HER2 status of nodal metastatic lesion may be more relevant for guiding anti-HER2 target therapy.
中文关键词	乳腺肿瘤 ; 淋巴转移 ; 基因,erbB-2 ; 原位杂交,荧光
英文关键词	Breast neoplasms Lymphatic metastasis Genes, erbB-2 In situ hybridization, fluorescence
语种	中文
国家	中国
收录类别	CSCD
WOS类目	MEDICINE GENERAL INTERNAL
WOS研究方向	General & Internal Medicine
CSCD记录号	CSCD:5722902
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/235551
作者单位	中国医学科学院北京协和医学院北京协和医院病理科, 100730
推荐引用方式 GB/T 7714	刘媛媛,武莎斐,梁智勇,等. 乳腺癌原发灶和淋巴结转移灶HER2基因状态对比分析[J],2016,45(6):392-396.
APA	刘媛媛,武莎斐,梁智勇,&曾瑄.(2016).乳腺癌原发灶和淋巴结转移灶HER2基因状态对比分析.中华病理学杂志,45(6),392-396.
MLA	刘媛媛,et al."乳腺癌原发灶和淋巴结转移灶HER2基因状态对比分析".中华病理学杂志 45.6(2016):392-396.