干旱区生态环境知识资源中心(Arid): 中成药及保健品中违禁添加20种非甾体抗炎药的SPE-HPLC-DAD 测定

Arid

	中成药及保健品中违禁添加20种非甾体抗炎药的SPE-HPLC-DAD 测定
其他题名	Determination of 20 NSAIDs Added Illegally in Chinese Patent Drugs and Health Products by Solid Phase Extraction-HPLC-DAD
	侯小梅 1; 冯安勇 2; 袁平 3; 陈志琼 1
来源期刊	中国医药工业杂志
ISSN	1001-8255
出版年	2016
卷号	47 期号:7 页码:910-914
中文摘要	建立了固相萃取-高效液相色谱-二极管阵列(SPE-HPLC-DAD)法同时测定中成药及保健品中可能违禁添加的20种非甾体抗炎药(NSAIDs)。样品经甲醇超声提取,以Oasis HLB固相萃取柱净化后检测。采用Waters XBridge Shield RP C_(18)色谱柱;以0.02 mol/L乙酸铵溶液(pH 5.0)和乙腈为流动相,梯度洗脱;检测波长230 nm和280 nm。结果表明,样品经净化后,基质对测定干扰较小,20种NSAIDs均在1~ 50 mg/ml范围内线性关系良好;检测限(LOD)为0.03~ 0.80 mg/kg。
英文摘要	A solid phase extraction-high performance liquid chromatography with diode array detector (SPEHPLC- DAD) method was established for the determination of 20 nonsteroidal anti-inflammatory drugs (NSAIDs) probably added illegally in Chinese patent drugs and health products. Samples were extracted with methanol by ultrasound, and the extract was cleaned up by an Oasis HLB SPE column. A Waters XBridge Shield RP C_(18) column was used, with the mobile phase of 0.02 mol/L ammonium acetate solution (pH 5.0)∶acetonitrile by gradient elution, at the detection wavelengths of 230 nm and 280 nm. The results showed that the interference of the matrix was low. It was linear for 20 NSAIDs in the range of 150 mg/ml. Their limits of detection were 0.030.80 mg/kg.
中文关键词	非甾体抗炎物 ; 固相萃取 ; 高效液相色谱法 ; 含量测定
英文关键词	nonsteroidal anti-infl ammatory drugs (NSAIDs) solid phase extraction HPLC determination
语种	中文
国家	中国
收录类别	CSCD
WOS类目	PHARMACOLOGY PHARMACY
WOS研究方向	Pharmacology & Pharmacy
CSCD记录号	CSCD:5754017
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/235543
作者单位	1.重庆医科大学药学院, 重庆 400016, 中国; 2.重庆市计量质量检测研究院第三分院, 重庆 402160, 中国; 3.重庆市永川食品药品检验所, 重庆 402160, 中国
推荐引用方式 GB/T 7714	侯小梅,冯安勇,袁平,等. 中成药及保健品中违禁添加20种非甾体抗炎药的SPE-HPLC-DAD 测定[J],2016,47(7):910-914.
APA	侯小梅,冯安勇,袁平,&陈志琼.(2016).中成药及保健品中违禁添加20种非甾体抗炎药的SPE-HPLC-DAD 测定.中国医药工业杂志,47(7),910-914.
MLA	侯小梅,et al."中成药及保健品中违禁添加20种非甾体抗炎药的SPE-HPLC-DAD 测定".中国医药工业杂志 47.7(2016):910-914.