干旱区生态环境知识资源中心(Arid): 超高效液相色谱串联质谱测定饮用水中PPCPs残留

Arid

	超高效液相色谱串联质谱测定饮用水中PPCPs残留
其他题名	Determination of Pharmaceuticals and Personal Care Products in Drinking Water by Ultra-high Performance Liquid Chromatography/Tandem Mass Spectrometry
	陈永艳; 吕佳; 韩嘉艺; 张岚; 叶必雄; 邢方潇
来源期刊	中国给水排水
ISSN	1000-4602
出版年	2016
卷号	32 期号:24 页码:126-132
中文摘要	建立了超高效液相色谱串联质谱(UPLC-MS/MS)同时测定饮用水中49种药物与个人护理品(PPCPs)残留的方法。采用Oasis HLB固相萃取柱对水样中的目标化合物进行富集净化,用液相色谱-串联质谱法进行分离和检测,以ACQUITY UPLC HSS T3色谱柱分离,以甲醇和0. 1 %甲酸水溶液为流动相进行梯度洗脱,质谱采用电喷雾正离子电离、多反应监测模式检测,内标法定量。结果表明,49种药物与个人护理品在生活饮用水中的三种不同加标量下的回收率分别为50. 3% ~124. 5% 、61. 7% ~ 123. 3% 和64. 3% ~ 124. 6%,相对标准偏差(n = 6)分别为1. 1% ~ 15.5%,0.3% ~11.3%和0.9% ~8.2% ;最低检测质量浓度在0. 05~5.73 ng/L之间。将建立的方法应用于北京某地表水、地下水以及市政水水样的分析,结果表明,该法操作简单、灵敏度高、选择性强,适用于饮用水中药物与个人护理品残留的测定。
英文摘要	An analytical method was developed to determine 49 pharmaceuticals and personal care products (PPCPs) in drinking water by ultra-high performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS). Water samples were enriched and purified with Oasis HLB SPE,separated through ACQUITY UPLC HSS T3 column, using 0. 1% formic acid solution and methanol as mobile phase,and detected by mass spectrometry in positive ion mode with multiple reaction monitoring using an electrospray ionization interface, quantified by an internal standard. The mean recoveries of the targeted 49 PPCPs spiked at three concentration levels were in the range of 50. 3% to 124. 5%, 61.7% to 123.3% and 64. 3% to 124. 6%, with relative standard deviations ( RSDs) (n =6) of 1. 1% to 15.5%, 0.3% to 11.3% and 0.9% to 8. 2%. The method quantification limits (MQL) were in the range of 0. 05 to 5. 73 ng/L. The proposed method was used to determine the 49 PPCPs in ground water, tap water and surface water in Beijing. The method for the 49 representative PPCPs is simple,sensitive, specific,and suitable for the determination of trace contaminant residues in drinking water.
中文关键词	固相萃取 ; 高效液相色谱-串联质谱法 ; 药物与个人护理品 ; 生活饮用水
英文关键词	solid phase extraction ( SPE ) ultra-high liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) pharmaceuticals and personal care products (PPCPs) drinking water
语种	中文
国家	中国
收录类别	CSCD
WOS类目	CONSTRUCTION BUILDING TECHNOLOGY
WOS研究方向	Construction & Building Technology
CSCD记录号	CSCD:5884491
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/235336
作者单位	中国疾病预防控制中心环境与健康相关产品安全所, 北京 100050, 中国
推荐引用方式 GB/T 7714	陈永艳,吕佳,韩嘉艺,等. 超高效液相色谱串联质谱测定饮用水中PPCPs残留[J],2016,32(24):126-132.
APA	陈永艳,吕佳,韩嘉艺,张岚,叶必雄,&邢方潇.(2016).超高效液相色谱串联质谱测定饮用水中PPCPs残留.中国给水排水,32(24),126-132.
MLA	陈永艳,et al."超高效液相色谱串联质谱测定饮用水中PPCPs残留".中国给水排水 32.24(2016):126-132.