干旱区生态环境知识资源中心(Arid): 含乳食品中17种塑化剂的检测

Arid

	含乳食品中17种塑化剂的检测
其他题名	Determination of 17 plasticizers in dairy food
	杜珍妮; 苗宏健; 吴永宁
来源期刊	卫生研究
ISSN	1000-8020
出版年	2016
卷号	45 期号:3 页码:465-469
中文摘要	目的采用固相萃取-超高效液相色谱-串联质谱技术(UPLC-MS /MS),建立含乳食品中17种塑化剂的检测方法。方法样品采用乙腈提取,经OASIS Prime HLB固相萃取柱净化。以BEH Phenyl(2.1 mm * 100 mm * 1.7 mum)色谱柱进行色谱分离,以电喷雾电离(ESI)串联质谱多反应检测模式(MRM)进行监测,同位素内标标准曲线法定量。结果17种塑化剂化合物在0.5~ 500 mug /L浓度范围内呈良好的线性关系,R~2 > 0.9990,检出限为1 ~ 14 mug /kg,加标回收率(n = 6)为89.8%~ 119.0%,相对标准偏差(RSD)为3.62%~ 12.60%,具有良好的重现性。结论UPLC-MS /MS法简单、准确、灵敏度高,特别是样品前处理快捷简便,适用于含乳食品中17种塑化剂的检测。
英文摘要	Objective A method was established for determination of 17 kinds of plasticizers in infant formula by solid-phase extraction coupled with UPLC-MS /MS. Methods The plasticizers were extracted from the infant formula with acetonitrile,and purified by solid phase extraction column named OASIS Prime HLB. The analytes were then separated by the chromatographic column (BEH Phenyl,2.1 mm * 100 mm * 1.7 mum). The ion fragment information analytes were obtained using ultra high performance liquid chromatography-tandem mass spectrometry under multiple reaction monitoring mode and the isotope internal standards were used to quantify by calibration curves. Results The method showed a good linearity (R~2 > 0.9990) in the range of 0.5 - 500 mug /L for 17 plasticizers analytes with average recovery rates of 89.8%- 119.0% (n = 6) and the relative standard deviation (RSD) within 3.62%- 12.60%. The limits of quantification (LOQ) were between 1 mug /kg and 14 mug /kg. Conclusion The method is simple, sensitive and accurate,and the sample pretreatment is very convenient especially,is suitable for the determination of 17 plasticizers in infant formula and dairy products.
中文关键词	超高效液相色谱-串联质谱法 ; 含乳食品 ; 塑化剂 ; 固相萃取
英文关键词	UHPLC-MS /MS dairy food plasticizer solid phase extraction
语种	中文
国家	中国
收录类别	CSCD
WOS类目	PUBLIC ENVIRONMENTAL OCCUPATIONAL HEALTH
WOS研究方向	Public, Environmental & Occupational Health
CSCD记录号	CSCD:5711345
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/235106
作者单位	国家食品安全风险评估中心, 北京 100021, 中国
推荐引用方式 GB/T 7714	杜珍妮,苗宏健,吴永宁. 含乳食品中17种塑化剂的检测[J],2016,45(3):465-469.
APA	杜珍妮,苗宏健,&吴永宁.(2016).含乳食品中17种塑化剂的检测.卫生研究,45(3),465-469.
MLA	杜珍妮,et al."含乳食品中17种塑化剂的检测".卫生研究 45.3(2016):465-469.