干旱区生态环境知识资源中心(Arid): 聚氯乙烯类食品包装材料中三甲基锡向食品模拟物的迁移规律

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	聚氯乙烯类食品包装材料中三甲基锡向食品模拟物的迁移规律
其他题名	Migration Pattern of Trimethyltin from PVC Food Packaging Materials to Food Simulants
	许欣欣; 陈慧玲; 毛丽莎; 胡辛楠
来源期刊	食品科学
ISSN	1002-6630
出版年	2016
卷号	37 期号:14 页码:193-197
中文摘要	目的:建立聚氯乙烯类包装材料和食品模拟物中三甲基锡的超高效液相色谱-串联质谱(ultra performance liquid chromatography-tandem mass spectrometry,UPLC-MS/MS)联用测定方法。用该方法研究聚氯乙烯中的三甲基锡向食品模拟物的迁移规律。方法:聚氯乙烯包装材料样品用乙酸乙酯提取。食品模拟物经阳离子固相萃取柱净化富集,洗脱液水浴条件下氮气吹干,残渣用流动相溶解,旋涡混匀,过0.22 mum微孔滤膜,经C_(18)色谱柱完成分离,MS/MS仪上采用多反应监测正离子模式测定三甲基锡,外标法定量。在设定的不同温度条件下,将聚氯乙烯包装材料浸泡于食品模拟物中,于不同的时间点移取浸泡液,经前处理后测定三甲基锡迁移量。结果:三甲基锡在0.1~100.0 mug/L范围内线性关系良好(相关系数r=0.9998),检出限为0.02 mug/L。在1.0、10.0、50.0 mug/L3个添加水平范围内的平均回收率为90.6%~97.3%,相对标准偏差不高于6.9%。测定结果显示,三甲基锡迁移量在水模拟物中为0.19~1.65 mug/L、在体积分数10%乙醇模拟物中为0.19~9.89 mug/L、在3 g/100 mL乙酸模拟物中为0.11~9.96 mug/L、在正己烷模拟物中为0.15~3.54 mug/L。结论:建立的阳离子固相萃取-UPLC-MS/MS联用法测定食品模拟物中三甲基锡的方法快速简单、准确有效,三甲基锡在体积分数10%乙醇溶液和3 g/100 mL乙酸溶液迁移量较高,且随温度升高、时间延长,迁移量增加,一定时间后达到迁移平衡。
英文摘要	Objective: To develop an ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for determining trimethyltin (TMT) in polyvinyl chloride (PVC) food packaging materials and four food simulants and to further study the migration pattern of TMT from the packaging materials to the food simulants. Methods: TMT was extracted from PVC food packaging materials with ethyl acetate. After purification and enrichment with OASIS MCX C_(18) cartridge, the eluate containing food simulants was evaporated to dryness with nitrogen in water bath, redissolved with the mobile phase, vortexed and filtered through a 0.22 mum membrane. The filtrate was detected by UPLC-MS-MS using positive ion electrospray ionization under multiple reaction monitoring (MRM) mode with a UPLC C_(18) column as separation column, and quantified by an external standard method. At different temperatures, PVC food packaging materials were soaked in four food simulants, namely, water, 10% ethanol solution, 3 g/100 mL acetic acid solution and n-hexane, respectively. At certain time points, the soaking solution was analyzed by UPLC-MS/MS. Results: The standard calibration curve of TMT was linear in the range of 0.1-100.0 mug/L with a correlation coefficient of 0.999 8. The recoveries at three spiked levels (1.0, 10.0 and 50.0 mug/L) ranged from 90.6% to 97.3%, with relative standard derivations (RSDs) lower than 6.9%. TMT was detected in the range of 0.19-1.65, 0.19-9.89, 0.11-9.96 and 0.15-3.54 mug/L in water, 10% ethanol solution 3 g/100 mL acetic acid solution and n-hexane, respectively. Conclusion: The solid phase extraction-UPLC-MS/ MS method is simple, reliable, accurate,and applicable to determinate TMT in food simulants. TMT in PVC food packaging materials easily migrates to 10% ethanol solution and 3 g/100 mL acetic acid solution. These results showed that TMT migration has positive correlations with temperature and time, but the process was balanced after a certain period of time.
中文关键词	超高效液相色谱-串联质谱 ; 三甲基锡 ; 食品模拟物 ; 聚氯乙烯 ; 食品包装材料
英文关键词	ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) trimethyltin food simulant polyvinyl chloride (PVC) food packaging materials
语种	中文
国家	中国
收录类别	CSCD
WOS类目	PUBLIC ENVIRONMENTAL OCCUPATIONAL HEALTH
WOS研究方向	Public, Environmental & Occupational Health
CSCD记录号	CSCD:5749915
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/234898
作者单位	深圳市疾病预防控制中心, 深圳, 广东 518055, 中国
推荐引用方式 GB/T 7714	许欣欣,陈慧玲,毛丽莎,等. 聚氯乙烯类食品包装材料中三甲基锡向食品模拟物的迁移规律[J],2016,37(14):193-197.
APA	许欣欣,陈慧玲,毛丽莎,&胡辛楠.(2016).聚氯乙烯类食品包装材料中三甲基锡向食品模拟物的迁移规律.食品科学,37(14),193-197.
MLA	许欣欣,et al."聚氯乙烯类食品包装材料中三甲基锡向食品模拟物的迁移规律".食品科学 37.14(2016):193-197.