干旱区生态环境知识资源中心(Arid): 超高效液相色谱-三重四级杆质谱联用仪同时测定水中多种痕量药品

Arid

	超高效液相色谱-三重四级杆质谱联用仪同时测定水中多种痕量药品
其他题名	Simultaneous Determination of Trace Pharmaceuticals in Environmental Water Using Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry
	吴春英 1; 谷风 2; 白鹭 2; 陆文龙 2
来源期刊	化学世界
ISSN	0367-6358
出版年	2016
卷号	57 期号:5 页码:268-275
中文摘要	应用超高效液相色谱-三重四极杆质谱联用仪(UPLC-MS/MS)建立了水中29种典型药品(pharmaceuticals)的分析方法。通过对固相萃取柱、淋洗液、流动相等的优化,确定以Oasis HLB固相萃取柱、甲醇为淋洗液、V(0.1%甲酸):V(甲醇)=7 : 3为流动相做水样预处理。在最优条件下,目标物在水中回收率均73%?124%,相对标准偏差(RSDs)在7.8%?13.2%,线性范围均在2?2 000 mug/L,各目标物标准品在UPLC-MS/MS系统中有效的线性相关(R~2)为0.997以上。该方法具有检测限低、回收率高等优点,经实际样品测试,可适用于环境水体中2 9种典型药品的同时检测,为微量有机物引起的水环境风险评价和控制的相关研究提供支持和帮助。
英文摘要	An analysis method for simultaneous determination of 29 typical pharmaceuticals in water samples was developed using ultra high performance liquid chromatography-three triple quadrupole mass spectrometer (UPLC-MS/MS). Oasis HLB solid phase extraction column, methanol as eluant and V(0.1 % formic acid) : V(methanol) = 7 : 3 as mobile phase were selected for sample pretreatment through optimization. Under optimal sample pretreatment procedures and instrument conditions,the target recoveries ranged from 69% to 124% in water, the relative standard deviation (RSDs) ranged from 7.8% to 13.2%, and the linear range was from 2 to 2 000 mug/L with correlation coefficients (R~2) above 0.997. The method can be applied to simultaneous determination of 29 typical pharmaceuticals in environmental water because of low detection limit and high recovery. It can provide support and help for related research on water environmental risk assessment and control of the micro-organic pollutants.
中文关键词	痕量药品 ; 固相萃取 ; 回收率
英文关键词	UPLC-MS/MS ultra performance liquid chromatography-mass spectrometry/mass spectrometry trace pharmaceuticals solid phase extraction recovery
语种	中文
国家	中国
收录类别	CSCD
WOS类目	CHEMISTRY ANALYTICAL
WOS研究方向	Chemistry
CSCD记录号	CSCD:5708878
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/234490
作者单位	1.吉林化工学院资源与环境工程学院, 环境模拟与污染控制国家重点联合实验室, 吉林 132022, 中国; 2.吉林化工学院资源与环境工程学院, 吉林 132022, 中国
推荐引用方式 GB/T 7714	吴春英,谷风,白鹭,等. 超高效液相色谱-三重四级杆质谱联用仪同时测定水中多种痕量药品[J],2016,57(5):268-275.
APA	吴春英,谷风,白鹭,&陆文龙.(2016).超高效液相色谱-三重四级杆质谱联用仪同时测定水中多种痕量药品.化学世界,57(5),268-275.
MLA	吴春英,et al."超高效液相色谱-三重四级杆质谱联用仪同时测定水中多种痕量药品".化学世界 57.5(2016):268-275.