干旱区生态环境知识资源中心(Arid): 固相萃取-气相色谱-质谱法同时测定水中9种药品及个人护理用品

Arid

	固相萃取-气相色谱-质谱法同时测定水中9种药品及个人护理用品
其他题名	Simultaneous determination of nine pharmaceuticals and personal care products in waters by solid phase extraction-gas chromatography-mass spectrometry
	贾妍艳; 谭建华; 徐晨; 汤嘉骏; 王赢利; 解启来
来源期刊	色谱
ISSN	1000-8713
出版年	2014
卷号	32 期号:3 页码:263-267
中文摘要	采用固相萃取-气相色谱-质谱联用技术，建立了水体中9种药品及个人护理用品（水杨酸、萘普生、布洛芬、对乙酰氨基酚、降固醇酸、三氯生、双氯酚酸、酮洛芬和双酚 A）的定量分析方法。水样品经稀盐酸调节至 pH =3后，采用 Oasis HLB 固相萃取小柱进行富集净化；选用三甲基氢氧化硫（ TMSH）为衍生化试剂，在常温条件下对目标物进行快速甲基化；以气相色谱-质谱法选择离子监测模式（GC-MS-SIM）进行检测，由2，4，5-涕丙酸为内标进行定量分析。本实验分别对固相萃取和衍生化等前处理条件进行了系统的研究。在优化的实验条件下，方法的回收率为50.7~115.4％，相对标准偏差均不高于10％，检出限为0.03~0.30mug / L，定量限为0．15~1．50mug / L。利用该方法对东莞市某农田灌溉水进行了分析，4种目标物在样品中有检出，最大质量浓度范围为0.176~0.998mug / L。结果表明该方法操作简便，灵敏可靠。
英文摘要	An analytical method has been developed and validated for the simultaneous deter-mination of nine pharmaceuticals and personal care products(PPCPs)in water samples,inclu-ding salicylic acid,naproxen,ibuprofen,paracetamol,clofibric acid,triclosan,diclofenac, ketoprofen,bisphenol A. The qualification and quantification of the target compounds were per-formed by gas chromatography-mass spectrometry in selected ion monitoring mode(GC-MS-SIM). The water samples were concentrated and purified through Oasis HLB cartridges after the pH value of the water was adjusted to 3,then derivatized with trimethyl sulfonium hydroxide (TMSH)at room temperature,and determined by GC-MS-SIM using 2,4,5-fenoprop as internal standard. The conditions for sample pretreatment(e. g. solid phase extraction and derivatiza-tion)were studied. Under the optimized conditions,the recoveries were ranged from 50. 7% to 115. 4% with the relative standard deviations lower than 10% . The limits of detection were in the range of 0. 03-0. 30 mug / L and the limits of quantification were in the range of 0.15-1.50 mug / L. The method has been successfully applied to monitor the occurrence of the PPCPs residues in agricultural irrigation water in Dongguan,Guangdong Province. The four compounds were detected at maximum mass concentration range of 0. 176-0. 998 mug / L. It proved that this analyt-ical method is sensitive,reliable and acceptable.
中文关键词	固相萃取 ; 衍生化 ; 气相色谱-质谱联用 ; 药品及个人护理用品 ; 水样
英文关键词	solid phase extraction(SPE) derivatization gas chromatography-mass spectrom-etry(GC-MS) pharmaceuticals and personal care products(PPCPs) waters
语种	中文
国家	中国
收录类别	CSCD
WOS类目	CHEMISTRY ANALYTICAL
WOS研究方向	Chemistry
CSCD记录号	CSCD:5087814
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/231535
作者单位	华南农业大学资源环境学院, 土壤环境与废物资源农业利用广东高校重点实验室, 广州, 广东 510642, 中国
推荐引用方式 GB/T 7714	贾妍艳,谭建华,徐晨,等. 固相萃取-气相色谱-质谱法同时测定水中9种药品及个人护理用品[J],2014,32(3):263-267.
APA	贾妍艳,谭建华,徐晨,汤嘉骏,王赢利,&解启来.(2014).固相萃取-气相色谱-质谱法同时测定水中9种药品及个人护理用品.色谱,32(3),263-267.
MLA	贾妍艳,et al."固相萃取-气相色谱-质谱法同时测定水中9种药品及个人护理用品".色谱 32.3(2014):263-267.