干旱区生态环境知识资源中心(Arid): 超高效液相色谱- 四极杆- 飞行时间质谱法快速筛查化妆品中18种香豆素类化合物

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	超高效液相色谱- 四极杆- 飞行时间质谱法快速筛查化妆品中18种香豆素类化合物
其他题名	Rapid Screening of 18 Coumarin Compounds in Cosmetics by Ultra Performance Liquid Chromatography - Quadrupole Time-of-Flight Mass Spectrometry
	马强; 白桦; 王超; 李文涛; 马会娟; 李晶瑞; 孟宪双; 陈云霞
来源期刊	分析测试学报
ISSN	1004-4957
出版年	2014
卷号	33 期号:3 页码:248-255
中文摘要	建立了化妆品中18种香豆素类化合物(二氢香豆素、7-羟基香豆素、6-甲氧基-7-羟基香豆素、6,7-二甲氧基香豆素、香豆素、7-甲氧基香豆素、4-甲基-7-羟基香豆素、补骨脂素、8-甲氧基补骨脂素、7-甲基香豆素、异补骨脂素、5-甲氧基补骨脂素、4-甲基-7-乙氧基香豆素、欧前胡素、2’,4,8-三甲基补骨脂素、8-羟基补骨脂素、异欧前胡素、环香豆素)的超高效液相色谱- 四极杆- 飞行时间质谱快速筛查方法。膏霜、水剂、香波、散粉、唇膏等不同类型的化妆品样品经超声提取后,样品提取液高速离心处理,浓缩上清液,以Oasis HLB 固相萃取柱净化,经Waters ACQUITY UPLC BEH C18色谱柱(150 mm * 2. 1 mm,1. 7 mum)在10min 内完成有效分离后,采用大气压化学电离- 四极杆- 飞行时间质谱进行筛查分析。18种香豆素类化合物的定量下限为10 ~ 60 mug /kg。在低、中、高3个加标水平的平均回收率为85. 2% ~ 95. 1%,相对标准偏差为3. 2%~ 8. 6%。该方法准确、快速、灵敏,为化妆品样品的高通量快速筛查提供了可靠实用的技术手段。
英文摘要	A comprehensive analytical method based on ultra performance liquid chromatography coupled with quadrupole - time-of-flight mass spectrometry(UPLC - Q - TOF - MS) was developed for the rapid screening of 18 coumarin compounds (e. g. dihydrocoumarin,7-hydroxycoumarin,6-methoxy- 7-hydroxycoumarin,6, 7-dimethoxycoumarin, coumarin, 7-methoxycoumarin, 4-methyl-7- hydroxycoumarin, psoralen, 8-methoxypsoralen, 7-methylcoumarin, isopsoralen, 5-methoxypsoralen, 4-methyl-7-ethoxycoumarin, imperatorin, 2’, 4, 8-trimethylpsoralen, 8-hydroxypsoralen, isoimperatorin and cyclocumarol) in cosmetics. Various cosmetic samples,including cream,lotion, shampoo,powder and lipstick,were extracted under ultrasonication. The extract was centrifuged, and the upper solution was concentrated with rotary evaporator. The reconstructed solution was then cleaned up with Oasis HLB solid phase extraction cartridge. The screening analysis was carried out by atmospheric chemical ionization - quadrupole - time-of-flight mass spectrometry after the chromatographic separation on a Waters ACQUITY UPLC BEH C18 (150 mm * 2. 1 mm,1. 7 mum) column within 10 min. The limits of quantitation(LOQs) for 18 coumarin compounds ranged from 10 mug /kg to 60 mug /kg. The mean recoveries at three spiked levels ranged from 85. 2% to 95. 1%,with relative standard deviations of 3. 2% - 8. 6%. The method is accurate,rapid and sensitive,and can provide a reliable and effective technique for the high-throughput screening of cosmetics.
中文关键词	超高效液相色谱- 四极杆- 飞行时间质谱 ; 化妆品 ; 香豆素类化合物 ; 快速筛查
英文关键词	ultra performance liquid chromatography - quadruple time-of-flight mass spectrometry(UPLC-Q-TOF-MS) cosmetics coumarin compounds rapid screening
语种	中文
国家	中国
收录类别	CSCD
WOS类目	CHEMISTRY ANALYTICAL
WOS研究方向	Chemistry
CSCD记录号	CSCD:5089367
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/231033
作者单位	中国检验检疫科学研究院, 北京 100123, 中国
推荐引用方式 GB/T 7714	马强,白桦,王超,等. 超高效液相色谱- 四极杆- 飞行时间质谱法快速筛查化妆品中18种香豆素类化合物[J],2014,33(3):248-255.
APA	马强.,白桦.,王超.,李文涛.,马会娟.,...&陈云霞.(2014).超高效液相色谱- 四极杆- 飞行时间质谱法快速筛查化妆品中18种香豆素类化合物.分析测试学报,33(3),248-255.
MLA	马强,et al."超高效液相色谱- 四极杆- 飞行时间质谱法快速筛查化妆品中18种香豆素类化合物".分析测试学报 33.3(2014):248-255.