干旱区生态环境知识资源中心(Arid): 水和土壤中磺胺和激素类药物的同时分析方法

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	水和土壤中磺胺和激素类药物的同时分析方法
其他题名	Method for Simultaneous Determination of Sulfonamides and Hormone-Type Drugs in Water and Soil
	陈传斌; 王娜; 孔德洋; 单正军; 高士祥
来源期刊	生态与农村环境学报
ISSN	1673-4831
出版年	2013
卷号	29 期号:3 页码:380-385
中文摘要	建立了一种水和土壤中磺胺嘧啶、磺胺甲嘧啶、磺胺噻唑、磺胺二甲嘧啶、磺胺二甲氧嘧啶、磺胺甲(口恶)唑6种磺胺类药物和17alpha雌二醇、17beta雌二醇、雌酮、雌三醇、炔雌醇、乙烷雌酚6种激素类药物同时分析的方法。具体步骤:水样过滤后使用Oasis HLB 固相萃取小柱进行净化富集;土壤样品经加速溶剂提取(ASE)之后过Oasis HLB小柱净化富集;采用超高效液相色谱串联质谱(UPLCMS/MS)进行检测,分别以乙腈和1 mL·L~(-1)甲酸溶液、乙腈和1 mL·L~(-1)氨水溶液作为流动相。磺胺在水和土壤中的回收率分别为87.4%~103.6%和58.2%~80.0%,激素在水和土壤中的回收率分别为84.8%~101.8%和62.8%~79.3%,相对标准偏差均小于10.3%。水和土壤中磺胺的检测限分别为0.11~0.24 ng·L~(-1)和0.01~0.02 ng·g~(-1),激素的检测限分别为0.31~2.14 ng·L~(-1)和0.03~0.21 ng·g~(-1)。用上述方法检测宿迁某典型养殖场周边的地表水和土壤,结果表明采用该方法检测环境样品中的磺胺和激素类药物是可行的。
英文摘要	A new method has been established for simultaneous determination of 6 sulfonamides, i.e. sulfadiazine, sulfamerazine, sulfathiazole, sulfamethazine, sulfadimethazine, sulfamethoxazole, and 6 hormone-type drugs, i.e. 17alpha-estradiol, 17beta-estradiol, estrone, estriol, 17alpha-ethinyl-estradiol and hexestrol. Specific steps of the method are as following: After being filtered, water samples get purified and concentrated through Oasis HLB solid-phase extraction (SPE) cartridges. After accelerated solvent extraction (ASE), soil samples get purified and concentrated through Oasis HLB cartridges. Then the water and soil samples are analyzed by UPLC-MS/MS, which uses solvent of acetonitrile-and-methanoic acid (1 mL·L~(-1)) and acetonitrile-and-ammonia (1 mL·L~(-1)) as mobile phase respectively. The mean recovery rate of sulfonamides in water and soil samples varied in the range of 87.4%-103.6% and 58.2%-80.0%, respectively, and that of the hormones in the range of 84.8%-101.8% and 62.8%-79.3%, respectively, with relative standard deviation all below 10.3%. Detection limit of the method (MDL) for sulfonamides in water and soil ranged from 0.11 to 0.24 ng·L~(-1) and from 0.01 to 0.02 ng·g~(-1), respectively, and for the hormones did from 0.31 to 2.14 ng·L~(-1) and from 0.03 to 0.21 ng·L~(-1), respectively. This method was applied for determination of sulfonamides and hormones in the soil and surface water around a swine farm typical in Suqian area, with results demonstrating that this method is applicable to the determination of sulfonamides and hormone-type drugs in the environment.
中文关键词	磺胺 ; 激素 ; 水 ; 土壤 ; 液相色谱串联质谱 ; 分析方法
英文关键词	sulfonamides hormone water soil LCMS/MS determination method
语种	中文
国家	中国
收录类别	CSCD
WOS类目	ENVIRONMENTAL SCIENCES
WOS研究方向	Environmental Sciences & Ecology
CSCD记录号	CSCD:4869751
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/230091
作者单位	南京大学环境学院, 污染控制与资源化研究国家重点实验室, 南京, 江苏 210023, 中国
推荐引用方式 GB/T 7714	陈传斌,王娜,孔德洋,等. 水和土壤中磺胺和激素类药物的同时分析方法[J],2013,29(3):380-385.
APA	陈传斌,王娜,孔德洋,单正军,&高士祥.(2013).水和土壤中磺胺和激素类药物的同时分析方法.生态与农村环境学报,29(3),380-385.
MLA	陈传斌,et al."水和土壤中磺胺和激素类药物的同时分析方法".生态与农村环境学报 29.3(2013):380-385.