干旱区生态环境知识资源中心(Arid): 高效液相色谱-串联质谱法测定化妆品中壬基苯酚

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	高效液相色谱-串联质谱法测定化妆品中壬基苯酚
其他题名	HPLC-MS/MS Determination of Nonylphenol in Cosmetics
	席海为; 马强; 刘茜; 王烨; 丁岚; 苏宁; 白桦; 王超
来源期刊	理化检验. B, 化学分册
ISSN	1001-4020
出版年	2012
卷号	48 期号:8 页码:970-973
中文摘要	提出了高效液相色谱-串联质谱法测定化妆品中壬基苯酚含量的方法。化妆品试液用甲醇-二氯甲烷(8+2)混合溶液超声提取30 min[唇膏类试样用无水乙醇-二氯甲烷(8+2)混合溶液],离心分离取上清液过Oasis HLB固相萃取柱净化。从SPE净化柱所得淋出液,以WatersXBridge C_(18)色谱柱(2.1 mm*150 mm,3.5mum)为固定相分离,以不同体积比的甲醇和氨水(0.1+99.9)溶液为流动相梯度洗脱,串联质谱进行测定。采用电喷雾负离子模式多反应监测,内标法定量。壬基苯酚的线性范围为10~500mug·L~(-1),测定下限(10S/N)为0.2 mg·kg。方法用于分析4种类型化妆品样品,回收率在83.1%~103.0%之间,相对标准偏差(n=6)在2.75%~9.24%之间。
英文摘要	A method of HPLC-MS/MS for the determination of nonylphenol in cosmetics was proposed.The sample was extracted ultrasonically with mixture of CH3OH-CH2Cl2(8 + 2) for 30 min except using mixture of C2H5OH-CH2Cl2(8+2) for lipstick.After centrifugation,the supernatant was taken for purification on Oasis HLB solid phase extraction column.The nonylphenol in the eluate from the SPE column was separated on Waters XBridge C_(18) column(2.1 mm*150 mm,3.5mum) by gradient elution with mixtures of CH3OH and ammonia (0.1 + 99.9) solution in different ratios,and determined by MS/MS.The negative electrospray ionization as well as multiple reactions monitoring mode was used in the detection.The internal standard method was used for quantification of nonylphenol.Linearity range of nonylphenol was kept from 10 to 500mug·L~(-1),with lower limit of determination(10S/N) of 0.2 mg·kg~(-1).The proposed method was applied to the analysis of 4 kinds of cosmetic samples,giving values of recovery in the range of 83.1%103.0%and RSD s(n=6) in the range of 2.75%9.24%.
中文关键词	高效液相色谱-串联质谱法 ; 壬基苯酚 ; 化妆品
英文关键词	HPLC-MS/MS Nonylphenol Cosmetics
语种	中文
国家	中国
收录类别	CSCD
WOS类目	CHEMISTRY ANALYTICAL
WOS研究方向	Chemistry
CSCD记录号	CSCD:4670512
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/228287
作者单位	中国检验检疫科学研究院, 北京 100123, 中国
推荐引用方式 GB/T 7714	席海为,马强,刘茜,等. 高效液相色谱-串联质谱法测定化妆品中壬基苯酚[J],2012,48(8):970-973.
APA	席海为.,马强.,刘茜.,王烨.,丁岚.,...&王超.(2012).高效液相色谱-串联质谱法测定化妆品中壬基苯酚.理化检验. B, 化学分册,48(8),970-973.
MLA	席海为,et al."高效液相色谱-串联质谱法测定化妆品中壬基苯酚".理化检验. B, 化学分册 48.8(2012):970-973.