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同位素稀释液质联用法测定鱼体中氯丙嗪的残留 | |
其他题名 | Determination of Chlorpromazine residue in fishies by isotope dilution liquid chromatography-tandem mass spectrometry |
于慧娟1; 王庆贺2; 戚隽渊2; 惠芸华1; 黄冬梅1; 金高娃1; 冯兵1 | |
来源期刊 | 海洋渔业
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ISSN | 1004-2490 |
出版年 | 2011 |
卷号 | 33期号:1页码:83-90 |
中文摘要 | 建立了高效液相色谱-串联质谱(HPLC/MS/MS)分析鱼体中氯丙嗪残留的方法?样品用乙腈提取,MCX固相萃取柱净化,氨化甲醇洗脱?在正离子模式下以电喷雾串联质谱仪进行测定,采用内标法定量,氘代氯丙嗪为内标物?以欧洲鳗鲡?鳜鱼和大口黑鲈为研究对象,在1.0?5.0?25.0mug/kg添加水平下,方法平均回收率为90.1%95.1%(批内),相对标准偏差为2.5%5.7%(批内)?方法定量限(S/N>10)为1.0mug/kg?方法检出限(S/N>3)为0.5mug/kg?实验结果表明:该方法简单?快速?准确度高?重复性好,适合于鱼类样品中氯丙嗪的残留检测 |
英文摘要 | A method to detect chlorpromazine residues in fish products was developed by using high performance liquid chromatography-tandem mass spectrometry(HPLC/ MS/MS). Chlorpromazine was extracted with acetonitrile from the test tissue. The extract was cleaned up and concentrated on an Oasis MCX cartridge, eluted by basic methanol and then analyzed by HPLC-MS/MS.The quantification was performed with internal standard method, with D6-Chlorpromazine as internal standard. The average recoveries were 90.1%-95.1%(Intraday) in the spiked range of 1-25 mug/kg in fish. The relative standard deviations were 2.5%-5.7%(Intraday).The limits of quantification(S /N >10) were 1.0 mug/kg and the limits of detection(S /N >3) were 0.5 mug/kg. Results indicated that the method used was easier, faster and more accurate |
中文关键词 | 氯丙嗪 ; 同位素稀释 ; 高效液相色谱-串联质谱 ; 欧洲鳗鲡 ; 鳜鱼 ; 大口黑鲈 |
英文关键词 | Chlorpromazine isotope dilution HPLC/MS/MS Anguilla Anguilla Siniperca chuatsi Micropterus salmoides |
语种 | 中文 |
国家 | 中国 |
收录类别 | CSCD |
WOS类目 | PHARMACOLOGY PHARMACY |
WOS研究方向 | Pharmacology & Pharmacy |
CSCD记录号 | CSCD:4146551 |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/226702 |
作者单位 | 1.中国水产科学研究院东海水产研究所, 上海 200090, 中国; 2.上海水产研究所, 上海 200433, 中国 |
推荐引用方式 GB/T 7714 | 于慧娟,王庆贺,戚隽渊,等. 同位素稀释液质联用法测定鱼体中氯丙嗪的残留[J],2011,33(1):83-90. |
APA | 于慧娟.,王庆贺.,戚隽渊.,惠芸华.,黄冬梅.,...&冯兵.(2011).同位素稀释液质联用法测定鱼体中氯丙嗪的残留.海洋渔业,33(1),83-90. |
MLA | 于慧娟,et al."同位素稀释液质联用法测定鱼体中氯丙嗪的残留".海洋渔业 33.1(2011):83-90. |
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