干旱区生态环境知识资源中心(Arid): 载ZnO/活性碳复合材料抗菌性能及安全性研究

Arid

	载ZnO/活性碳复合材料抗菌性能及安全性研究
其他题名	Evaluation on Antibacterial Affects and Bio-safety of ZnO/active Carbon Composite Material
	韩绪军 1; 张立波 2; 冯悦 1; 唐颖蕾 1; 魏大巧 1; 彭金辉 2; 夏雪山 1
来源期刊	生物技术通报
ISSN	1002-5464
出版年	2010
期号	1 页码:200-204
中文摘要	废催化剂微波烧结法制备的ZnO/活性碳复合材料,在多孔活性炭表面附载有ZnO,是一种新型的环保材料.为评价其抗菌活性和使用安全性,本研究进行了材料对金黄色葡萄球菌、大肠杆菌、枯草芽孢杆菌及酵母菌的抑菌试验,结果表明ZnO/活性碳复合材料有很好的抑制细菌增殖效果,低浓度下(0.1 mug/mL)作用2 h的抑菌率能达到90%以上,对真菌-酵母菌的抑制活性相对较低;经细胞毒性试验、动物口服急性毒性试验,皮肤过敏性试验发现,材料对小鼠经口灌喂半致死剂量(LD50)>2 000 mg/kg,对兔皮肤刺激性积分为0,对细胞生长无影响,属于实际生物无毒级.试验结果表明ZnO/活性碳复合材料具有很好的抗菌效果及使用安全性.
英文摘要	As a novel environmental protection material,the ZnO/ active carbon composite material is prepared with microwave sintering methods from deserted catalyst, which carry ZnO in its plentiful holes. To evaluate its antibacterial affects and bio-safety, the experiment of anti-bacteria and anti-fungi was conducted. The results showed that more than 90% bacteria were inactivated when Escherichia coli, Staphylococcus aureaus and B.subtilis were incubated at 37℃ for two hours together with material. In comparison, its effect on yeast is low. The cultured cell toxicity, animal oral acute toxicity and skin allergy tests were also performed. According the its effects, the oral LD50 of the material for mice was more than 2 000 mg/kg, its stimulating score on the rabbit skin was zero, and the cells can grew normally, which suggested its high bio-safety. These findings indicate this ZnO/ active carbon composite material has a good anti-bacterial affects and could be used bio-safely.
中文关键词	活性碳 ; 抗菌作用 ; 抑菌率 ; 生物安全性
英文关键词	ZnO ZnO Activated carbon Antibacterial effect Rate of antibacteria Biosafety
语种	中文
国家	中国
收录类别	CSCD
WOS类目	CELL BIOLOGY
WOS研究方向	Cell Biology
CSCD记录号	CSCD:3821148
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/225581
作者单位	1.昆明理工大学生命科学与技术学院, 昆明, 云南 650224, 中国; 2.昆明理工大学材料与冶金工程学院, 昆明, 云南 650093, 中国
推荐引用方式 GB/T 7714	韩绪军,张立波,冯悦,等. 载ZnO/活性碳复合材料抗菌性能及安全性研究[J],2010(1):200-204.
APA	韩绪军.,张立波.,冯悦.,唐颖蕾.,魏大巧.,...&夏雪山.(2010).载ZnO/活性碳复合材料抗菌性能及安全性研究.生物技术通报(1),200-204.
MLA	韩绪军,et al."载ZnO/活性碳复合材料抗菌性能及安全性研究".生物技术通报 .1(2010):200-204.