干旱区生态环境知识资源中心(Arid): MRI引导下氩氦刀冷冻小型猪大脑的实验观察

Arid

	MRI引导下氩氦刀冷冻小型猪大脑的实验观察
其他题名	Experimental observation of cryoablation in miniswine’s cerebrum guided by MRI
	张月高 1; 肖越勇 2; 潘隆盛 3; 张肖 2; 周振鸿 4
ISSN	1672-8475
出版年	2009
卷号	6 期号:1 页码:28-30
中文摘要	目的观察MRI引导下氩氦刀冷冻正常小型猪大脑的急慢性损伤.方法在MRI引导下应用氩氦刀冷冻治疗系统对小型猪左侧顶部大脑进行冷冻消融,饲养3周后同法冷冻右侧顶部脑组织,随即处死动物并取出大脑,10%甲醛溶液固定,将猪大脑整体经顶冠状切片病检.结果第一次冷冻后急性期(1周)饲养观察动物无呕吐.大体标本于陈旧灶局部可见脑萎缩表现,新鲜冷冻灶皮层可见淤血并局部肿胀,边界清楚;镜下观察见陈旧灶大片坏死,其周围环绕明显炎性细胞浸润带;新鲜冷冻灶灰质内有多量破碎的红细胞并淤血;陈旧灶和新鲜灶白质内髓鞘结构均消失.结论氩氦刀冷冻消融可完全破坏正常脑组织,急性期町致脑肿胀,慢性期可引起周围炎性反应.
英文摘要	Objective To observe the acute and chronic impair of cryoablation in normal miniswines cerebrum guided by MRI. Methods A cryoablation focus in the left parietal cerebrum of a miniswine was produced by cryocare surgical system guided by MRI.Three weeks later the same management was implemented in the right parietal cerebrum of the same animal. It was sacrificed immediately, its brain was dislodged entirely arid retained by 10% formalin. Pathologic inspection of trans-parietal cerebrum entirety was performed. Results The animal was breaded without vomitting during the acute stage (one week) after the cryoabalation of the first time. In the general specimen, encephala trophy could be found in olden cryoablation focus, and in fresh cryoablation focus the stagnated blood with cerebral swelling was found obviously in the cortex with clear boundary. Under microscopy, a large area of cellular necrosis existed in olden focus with apparently a-round inflammatory cell infiltrating. Sackful cracked red blood cell existed in fresh cryoablation focus. Medullary sheath structure of white substance was all eliminated in the slices of Luxol fast-Blue staining. Conclusion The normal miniswine cerebral tissue could be destroyed completely by cryocare surgical system. Cerebral swelling could be remained in acute stage, and circular inflammatory reaction could be induced in chronic stage.
中文关键词	氩氦刀 ; 冷冻治疗 ; 磁共振成像
英文关键词	Cryocare surgical system Cryoablation Magnetic resonance imaging
语种	中文
国家	中国
收录类别	CSCD
WOS类目	MEDICINE GENERAL INTERNAL
WOS研究方向	General & Internal Medicine
CSCD记录号	CSCD:3572070
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/224502
作者单位	1.解放军总医院学员队, 北京 100853, 中国; 2.解放军总医院放射科, 北京 100853, 中国; 3.解放军总医院神经外科, 北京 100853, 中国; 4.解放军总医院病理科, 北京 100853, 中国
推荐引用方式 GB/T 7714	张月高,肖越勇,潘隆盛,等. MRI引导下氩氦刀冷冻小型猪大脑的实验观察[J],2009,6(1):28-30.
APA	张月高,肖越勇,潘隆盛,张肖,&周振鸿.(2009).MRI引导下氩氦刀冷冻小型猪大脑的实验观察.,6(1),28-30.
MLA	张月高,et al."MRI引导下氩氦刀冷冻小型猪大脑的实验观察".6.1(2009):28-30.