干旱区生态环境知识资源中心(Arid): 同位素稀释液相色谱-串联质谱法测定化妆品中残留的丙烯酰胺

Arid

	同位素稀释液相色谱-串联质谱法测定化妆品中残留的丙烯酰胺
其他题名	Determination of acrylamide residue in cosmetics by isotope dilution-liquid chromatographytandem mass spectrometry
	马强; 王超; 白桦; 王星; 张庆; 肖海清; 闫研; 董益阳; 王宝麟
ISSN	1000-8713
出版年	2009
卷号	27 期号:6 页码:856-859
中文摘要	建立了化妆品中丙烯酰胺残留的同位素稀释液相色谱-串联质谱的分析方法.水溶性化妆品样品以水为提取溶剂进行提取,提取液经高速离心处理后,上清液用Oasis HLB固相萃取柱净化;脂溶性化妆品样品以正己烷和水混合溶剂液-液分配萃取.经Waters Atlantis T3色谱柱(150 mm*2.1 mm,3 mum)分离后在多反应监测模式下进行串联质谱定性及定量分析,以~(13)C_3-丙烯酰胺为内标定量.方法的定量限为0.1 mg/kg,在0.1～1.0 mg/kg 3个添加水平范围内的平均回收率为87.7% ～95.8%,日内测定精密度均小于10%,日间测定精密度均小于12% .该方法能够满足化妆品中丙烯酰胺残留的检测要求.
英文摘要	A comprehensive analytical method based on isotope dilution-liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed for the determination of acrylam-ide residue in cosmetics. Water-soluble cosmetic sample was extracted with water, and the ex-tract was centrifuged, then the upper solution was cleaned up by an Oasis HLB solid phase ex-traction cartridge. Oil-soluble cosmetic sample was extracted by liquid-liquid partition with n-hexane and water. The qualitative and quantitative analyses were carried out for the analyte in the multiple reaction monitoring (MRM) mode after the chromatographic separation on a Wa-ters Atlantis T3 column (150 mm * 2. 1 mm, 3 mum). The quantification was performed with ~(13)C_3-acrylamide as internal standard. The limit of quantification (LOQ) for acrylamide was 0. 1 mg/kg. The mean recoveries were 87. 7% -95. 8% at the spiked levels of 0.1-1.0 mg/kg with the intra-day precision less than 10% and the inter-day precision less than 12%. The method is suitable for the determination of acrylamide in cosmetics.
中文关键词	同位素稀释 ; 液相色谱-串联质谱 ; 丙烯酰胺 ; 化妆品
英文关键词	isotope dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) acrylamide cosmetics
语种	中文
国家	中国
收录类别	CSCD
WOS类目	CHEMISTRY ANALYTICAL
WOS研究方向	Chemistry
CSCD记录号	CSCD:3716231
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/223997
作者单位	中国检验检疫科学研究院, 北京 100123, 中国
推荐引用方式 GB/T 7714	马强,王超,白桦,等. 同位素稀释液相色谱-串联质谱法测定化妆品中残留的丙烯酰胺[J],2009,27(6):856-859.
APA	马强.,王超.,白桦.,王星.,张庆.,...&王宝麟.(2009).同位素稀释液相色谱-串联质谱法测定化妆品中残留的丙烯酰胺.,27(6),856-859.
MLA	马强,et al."同位素稀释液相色谱-串联质谱法测定化妆品中残留的丙烯酰胺".27.6(2009):856-859.