干旱区生态环境知识资源中心(Arid): 同位素稀释液相色谱-串联质谱法测定化妆品中的N-亚硝基二乙醇胺

Arid

	同位素稀释液相色谱-串联质谱法测定化妆品中的N-亚硝基二乙醇胺
其他题名	Determination of N-nitrosodiethanolamine in cosmetics by isotope dilution-liquid chromatography-tandem mass spectrometry
	马强; 王超; 白桦; 王星; 董益阳; 武婷; 张庆; 王军兵; 唐英章
ISSN	1000-8713
出版年	2009
卷号	27 期号:3 页码:283-287
中文摘要	建立了化妆品中N-亚硝基二乙醇胺(NDELA)的同位素稀释液相色谱-串联质谱分析方法.水溶性化妆品样品以水为提取溶剂提取,样品提取液经高速离心处理后,上清液过Oasis HLB固相萃取柱净化.脂溶性化妆品样品用二氯甲烷和水混合溶剂进行液-液分配萃取.NDELA经Waters Atlantis T3色谱柱(150 mm*2.1 mm,3 mum)分离后在多反应监测模式下进行串联质谱定性及定量分析,以d8-NDELA为内标定量.NDELA的方法定量限为50 mug/kg;在50～250 mug/kg的3个添加水平范围内的平均回收率为89.1% ～98.2% ,日内精密度均小于9% ,日间精密度均小于11% .该方法能够满足化妆品中NDELA的检测要求.
英文摘要	A comprehensive analytical method based on isotope dilution-liquid chromatography-tandem mass spectrometry has been developed for the determination of N-nitrosodiethano-lamine in cosmetics. Water-soluble cosmetic samples were extracted with water. The extract was centrifuged, then the upper solution was cleaned up by an Oasis HLB solid phase extrac-tion cartridge. Oil-soluble cosmetic samples were extracted by liquid-liquid partition with di-chloromethane and water. Qualitative and quantitative analyses were carried out for the analyte under the multiple reaction monitoring (MRM) mode after the chromatographic separation on a Waters Atlantis T3 column (150 mm *2.1 mm, 3 mum ). The quantitation was performed with deuterated iV-nitrosodiethanolamine as internal standard. The limit of quantitation (LOQ) for N-nitrosodiethanolamine was 50 mug/kg. The mean recoveries were 89. 1% - 98. 2% at the spiked levels of 50 - 250 mug/kg, with the intra-day precision less than 9% and the inter-day pre-cision less than 11%. The method is suitable for the determination of NDELA in cosmetics.
中文关键词	同位素稀释 ; 液相色谱-串联质谱 ; N-亚硝基二乙醇胺 ; 化妆品
英文关键词	isotope dilution liquid chromatography-tandem mass spectrometry N-nitrosodi-ethanolamine cosmetics
语种	中文
国家	中国
收录类别	CSCD
WOS类目	CHEMISTRY ANALYTICAL
WOS研究方向	Chemistry
CSCD记录号	CSCD:3608624
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/223993
作者单位	中国检验检疫科学研究院, 北京 100123, 中国
推荐引用方式 GB/T 7714	马强,王超,白桦,等. 同位素稀释液相色谱-串联质谱法测定化妆品中的N-亚硝基二乙醇胺[J],2009,27(3):283-287.
APA	马强.,王超.,白桦.,王星.,董益阳.,...&唐英章.(2009).同位素稀释液相色谱-串联质谱法测定化妆品中的N-亚硝基二乙醇胺.,27(3),283-287.
MLA	马强,et al."同位素稀释液相色谱-串联质谱法测定化妆品中的N-亚硝基二乙醇胺".27.3(2009):283-287.