干旱区生态环境知识资源中心(Arid): 皮肤Rosai-Dorfman病的皮损临床表现及组织病理特征14例分析

Arid

	皮肤Rosai-Dorfman病的皮损临床表现及组织病理特征14例分析
其他题名	Clinicohistopathologic features of cutaneous Rosai-Dorfman disease: a study of 14 cases
	孔蕴毅 1; 孔今城 2; 罗燕 3; 陆洪芬 1; 施达仁 1
ISSN	1000-4963
出版年	2009
卷号	38 期号:3 页码:137-140
中文摘要	目的:探讨皮肤Rosai-Doffman病(CRDD)的皮损临床表现特征,结合组织病理、免疫表型和鉴别诊断可提高CRDD的正确诊断.方法:收集14例CRDD患者资料,分析其临床表现特征并进行门类分型,对标本进行组织病理和免疫组化染色观察.结果:14例CRDD患者的皮损表现可分为丘疹结节制(64.7%),浸润斑块型(5.9%)及肿瘤样型(29.4%)3种基本类型,无淋巴结增大等其他系统性病变.组织病理和免疫表型特点为真皮和皮下脂肪组织内数量不一的S-100蛋白阳性大型组织细胞,伴大量以淋巴细胞和浆细胞为主的混合性炎性细胞浸润,组织细胞胞质内常吞有数量多少不一的淋巴细胞.1例脉管内可见组织细胞.少数患者出现淋巴滤泡、纤维化及脂膜炎样和血管炎样组织病理形态.结论:CRDD皮损表现多种多样,3种基本皮损类型的分型方法能提高临床对CRDD诊断的皮损鉴别能力,结合组织病理改变和免疫表型可与多种皮肤病和皮肤肿瘤作鉴别.CRDD可复发,应作长期随访.
英文摘要	Objective: To improve the diagnosis of cutaneous Rosai-Dorfman disease (CRDD) by investigating the clinical, pathological and imtnunophenotypic features of this disease. Methods: The data of 14 cases of CRDD were collected. The clinical category was classified according the features of clinical manifestations of these patients. The histopathologie and im-munohistochemical studies were performed in all oases. Results: The skin lesions of 14 patients were divided into 3 main types: papulonodular type (64.7%), infiltrating plaque type (5.9%) and tumor type (29.4%). No other systemic disease such as lymphadenopathy was found. Mixed inflammatory cell infiltration in the dermis and submtis, mainly lymphocytes, plasma cells, and a variable number of S-100 positive histiocytes, was shown by histopathology and immunohistochemistry. The presence of lymphocytes engulfed within the histiocytic cytoplasm, namely emperipolesis, was seen. Few histiocytes between vascular spaces were found in one case. Lymph follicle, fibrosis, panniculitis-like change and vasculitis-like change were seen in a few cases. Conclusions: The classification of the skin lesions into three types, combined with histopathologie and immunophenotypic features, are helpful for the diagnosis of CRDD, especially for the differentiation of it from various other cutaneous neoplastic and non-neoplastic skin diseases.
中文关键词	Rosai-Doffman病,皮肤 ; 皮损 ; 鉴别诊断
英文关键词	Rosai-Dorfman disease, cutaneous skin lesions differential diagnosis
语种	中文
国家	中国
收录类别	CSCD
WOS类目	MEDICINE GENERAL INTERNAL
WOS研究方向	General & Internal Medicine
CSCD记录号	CSCD:3523166
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/223921
作者单位	1.复旦大学附属肿瘤医院病理科, 上海 200032, 中国; 2.复旦大学附属临床病理诊断中心, 上海 200032, 中国; 3.复旦大学附属华山医院皮肤病理室, 上海 200040, 中国
推荐引用方式 GB/T 7714	孔蕴毅,孔今城,罗燕,等. 皮肤Rosai-Dorfman病的皮损临床表现及组织病理特征14例分析[J],2009,38(3):137-140.
APA	孔蕴毅,孔今城,罗燕,陆洪芬,&施达仁.(2009).皮肤Rosai-Dorfman病的皮损临床表现及组织病理特征14例分析.,38(3),137-140.
MLA	孔蕴毅,et al."皮肤Rosai-Dorfman病的皮损临床表现及组织病理特征14例分析".38.3(2009):137-140.