干旱区生态环境知识资源中心(Arid): 固相萃取-超高效液相色谱串联质谱法测定城市污水中5种beta-受体阻断剂

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	固相萃取-超高效液相色谱串联质谱法测定城市污水中5种beta-受体阻断剂
其他题名	Determination of 5 beta-Adrenergic Receptor Blockers in Sewage by Solid Phase Extraction and Ultra Performance Liquid Chromatography/Tandem Mass Spectrometry
	柳晋杰 1; 张晶 2; 邵兵 2; 李青山 1
ISSN	1001-6929
出版年	2009
卷号	22 期号:7 页码:862-867
中文摘要	beta-受体阻断剂是一类常用的心血管疾病治疗药物.建立了城市污水中索他洛尔、普萘洛尔、卡维地洛、奈比洛尔和纳多洛尔5种beta-受体阻断剂的超高效液相色谱-串联质谱联用检测方法.水样经MCX固相萃取小柱富集、净化,采用0.1%甲酸水溶液与乙腈为流动相进行梯度洗脱,经BEH C18色谱柱分离,通过多反应监测模式进行测定.该方法对5种beta-受体阻断剂的线性范围为0.1～100.0 mug/L,相关系数(2)均大于0.99.污水中索他洛尔、普萘洛尔、卡维地洛、奈比洛尔和纳多洛尔的定量限为0.2～2.0 ng/L,加标回收率为54.1%～113.4%,相对标准偏差小于22%,可用于城市污水中相关物质的分析测定.
英文摘要	beta-Adrenergic receptor blocker is an important kind of pharmaceutical mainly used in cardiovascular disease therapy. An ultra performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) method was developed to analyze simultaneously S /3-adrenergic receptor blockers (sotalol, propranolol, carvedilol, nebivolol and nadolol) in sewage. Target compounds in sewage samples were concentrated and purified by an Oasis MCX cartridge, and then separated on a BEH C18 column using a binary mobile phase gradient with water containing 0.1% formic acid and acetonitrile. As a result, a well-shaped peak was obtained on the chromatogram of every analyte under the multi-reaction monitoring (MRM) mode. The assay for 5 beta-adrenergic receptor blockers were linear over the range of 0.1-100.0 mug/L, with correlation coefficient (R~2 ) > 0.99. limits of quantitation (LOQ) of target compounds in sewage sample ranged from 0.2 to 2.0 ng/L. Recoveries of the 5 beta-adrenergic receptor blockers (spiked in sewage samples at three concentration levels) ranged from 54.1%-113.4% , with relative standard deviations ( RSD) less than 22% . This method can be applied to the determination of target drugs in sewage samples.
中文关键词	超高效液相色谱-串联质谱(UPLC-MS/MS) ; beta-受体阻断剂 ; 城市污水 ; 固相萃取
英文关键词	ultra performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) beta-adrenergic receptor blockers sewage solid phase extraction (SPE)
语种	中文
国家	中国
收录类别	CSCD
WOS类目	ENVIRONMENTAL SCIENCES
WOS研究方向	Environmental Sciences & Ecology
CSCD记录号	CSCD:3592442
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/223850
作者单位	1.山西医科大学药学院, 太原, 山西 030001, 中国; 2.北京市疾病预防控制中心, 北京 100013, 中国
推荐引用方式 GB/T 7714	柳晋杰,张晶,邵兵,等. 固相萃取-超高效液相色谱串联质谱法测定城市污水中5种beta-受体阻断剂[J],2009,22(7):862-867.
APA	柳晋杰,张晶,邵兵,&李青山.(2009).固相萃取-超高效液相色谱串联质谱法测定城市污水中5种beta-受体阻断剂.,22(7),862-867.
MLA	柳晋杰,et al."固相萃取-超高效液相色谱串联质谱法测定城市污水中5种beta-受体阻断剂".22.7(2009):862-867.