干旱区生态环境知识资源中心(Arid): 鱼肉类罐头中双酚-二环氧甘油醚的固相萃取/HPLC-MS/MS法检测

Arid

	鱼肉类罐头中双酚-二环氧甘油醚的固相萃取/HPLC-MS/MS法检测
其他题名	Determination of Bisphenol Diglycidyl Ethers in Fish Canned Foodstuffs by Solid-phase Extraction/HPLC-MS/MS
	张朝晖 1; 罗生亮 2; 吴少林 2; 赵鑫 1; 刘文涛 1; 云环 1
ISSN	1004-4957
出版年	2009
卷号	28 期号:6 页码:714-719
中文摘要	建立了鱼肉类罐头中内分泌干扰物质双酚A二缩水甘油醚(BADGE)及其衍生物BADGE·H_2O、BADGE·2H_2O、BADGE·2HCl、BADGE·HCl·H_2O和双酚F二缩水甘油醚(BFDGE)及其衍生物BFDGE·2H_2O、BFDGE·2HCl 8种双酚-二环氧甘油醚的固相萃取/液相色谱-电喷雾串联质谱分析方法.以叔丁基甲醚为提取溶剂,采用超声波辅助溶剂萃取法萃取,萃取液用Waters Oasis HLB固相萃取柱进行净化浓缩.以Thermo Hypersil Gold C_18色谱柱为分离柱,在正离子模式下以电喷雾电离串联质谱仪进行测定.考察了流动相组分和流动相添加剂对质谱离子化效率的影响,8种双酚-二环氧甘油醚在1.0 ～100.0 mug/L范围内线性关系良好(r≥0.99).在2.0、10.0和50.0 mug/kg的添加水平下,8种目标化合物的回收率为83% ～99%,相对标准偏差小于9.0%,方法的检出限为0.13 ～0.30 mug/kg.方法具有较高的灵敏度和准确度,能够满足鱼肉类罐头食品中双酚-二环氧甘油醚残留量的快速检测.
英文摘要	A comprehensive analytical method based on solid-phase extraction/high liquid chromatog-raphy - electrospray ionization tandem mass spectrometry was developed for measuring 8 exogenous endocrine disruptors-bisphenol diglycidyl ethers, including BADGE, BADGE ·H_2O, BADGE · 2H_2O, BADGE · 2HCl, BADGE ·HCl · H_2O, BFDGE, BFDGE ·2H_2O, BFDGE · 2HCl, in fish canned foodstuffs. The samples were extracted with methyl tertiary butyl ether by ultrasonic wave assistant extraction (UAE). The extracts were cleaned up and concentrated on Waters Oasis HLB column. The targeted compounds were analyzed by HPLC - MS/MS under positive ion mode using Thermo Hypersil Gold C_18 column as analytical column. Effects of mobile phase and additives on ionization were also discussed. Under the optimal conditions, the calibration curves showed a good linearity in the concentration range of 1.0- 100. 0 mug/L for 8 target compounds. The correlation coefficients (r) were no less than 0. 99. Recoveries of 8 analytes at the spiked level of 2. 0, 10. 0 and 50. 0 mug/kg ranged from 83% to 99% with RSDs less than 9. 0% . The detection limits of the method ranged from 0. 13 to 0. 30 mug/kg. The method was sensitive and accurate, and was suitable for the rapid determination of exogenous endocrine disruptors-bisphenol diglycidyl ethers in fish canned foodstuffs.
中文关键词	高效液相色谱-电喷雾质谱/质谱 ; 固相萃取 ; 双酚-二环氧甘油醚 ; 鱼肉类罐头
英文关键词	HPLC-ESI MS/MS solid-phase extraction bisphenol diglycidyl ethers fish canned foodstuffs
语种	中文
国家	中国
收录类别	CSCD
WOS类目	CHEMISTRY ANALYTICAL
WOS研究方向	Chemistry
CSCD记录号	CSCD:3516845
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/223482
作者单位	1.北京出入境检验检疫局, 北京 100026, 中国; 2.南昌航空大学, 南昌, 江西 330063, 中国
推荐引用方式 GB/T 7714	张朝晖,罗生亮,吴少林,等. 鱼肉类罐头中双酚-二环氧甘油醚的固相萃取/HPLC-MS/MS法检测[J],2009,28(6):714-719.
APA	张朝晖,罗生亮,吴少林,赵鑫,刘文涛,&云环.(2009).鱼肉类罐头中双酚-二环氧甘油醚的固相萃取/HPLC-MS/MS法检测.,28(6),714-719.
MLA	张朝晖,et al."鱼肉类罐头中双酚-二环氧甘油醚的固相萃取/HPLC-MS/MS法检测".28.6(2009):714-719.