干旱区生态环境知识资源中心(Arid): 涤痰开窍汤对脑卒中后抑郁大鼠行为能力及脑内神经递质的影响

Arid

	涤痰开窍汤对脑卒中后抑郁大鼠行为能力及脑内神经递质的影响
其他题名	Effect of Ditan Kaiqiao Decoction on the Behavioral Ability and Intracerebral Neurotransmitter of Rats with Post-Stroke Depression
	裘涛; 陈眉; 代建峰; 吴乐程; 张宾辉
ISSN	1001-1668
出版年	2007
卷号	48 期号:8 页码:735-737
中文摘要	目的探讨涤痰开窍汤对脑卒中后抑郁(PSD)模型大鼠行为能力及脑内神经递质的影响.方法采用双侧颈总动脉永久性结扎后予以行为限制制备PSD大鼠模型,随机分为模型组、涤痰开窍组、氟西汀组,并设假手术组,采用RP-HPLC-荧光检测法测定大鼠海马区单胺类神经递质的变化,并观察大鼠自发性行为改变.结果模型组大鼠行为能力下降(P＜0.01或P＜0.05),海马区5-羟色胺、5-羟基吲哚乙酸、多巴胺、去甲肾上腺素水平下调(P＜0.05).经盐酸氟西汀、涤痰开窍汤治疗后大鼠的水平活动、垂直活动及清洁活动均较模型组改善,脑内单胺类神经递质水平提高(P＜0.05).结论大鼠双侧颈总动脉永久性结扎结合行为限制可为卒中后抑郁的实验及临床研究提供较为理想的动物模型.涤痰开窍汤可以改善脑卒中后抑郁大鼠的行为能力及脑内单胺类神经递质水平.
英文摘要	Objective To study the effect of Ditan Kaiqiao Decoction on the behavioral ability arid intracerebral neurotransmitter of rats with post-stroke depression（PSD）. Methods After the permanent ligation of bilateral common carotid arteries was performed, the behavioral limitation was applied to make PSD model rat and they were randomized into Model group, Ditan Kaiqiao group, Fluoxetine group and Pseudooperation group. The changes of monoamine neurotransmitter of hippocampal region were tested by RP-HPLC fluoroscopic examination and the autonomy behavioral changes were observed. Results The behavioral ability of Model group decreased （P〈0. 01 or P〈0.05）. 5-HT, 5-HIAA, DA and NE of hippocampal region were lowered （P〈0.05）. With the treatment of fluoxetine hydroehloride and Ditan Kaiqiao Decoction, the horizontal movement, vertical movement and clean movement of rats were improved in comparison with Model group, while the intracerebral monoamine neurotransmitter increased （P〈0.05）. Conclusion The permanent ligation of bilateral common carotid artery in combination of behavioral limitation could provide the ideal animal models for experiment and clinical study of PSD. Ditan Kaiqiao Decoction could improve the behavioral ability and intracerebral neurotransmitter of PSD rats.
中文关键词	涤痰开窍汤 ; 脑卒中后抑郁 ; 行为能力 ; 神经递质
英文关键词	Ditan Kaiqiao Decoction Post-stroke depression Behavioral ability neurotransmitter
语种	中文
国家	中国
收录类别	CSCD
WOS类目	MEDICINE GENERAL INTERNAL
WOS研究方向	General & Internal Medicine
CSCD记录号	CSCD:2915406
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/221903
作者单位	浙江省中医院神经内科, 杭州, 浙江 310006, 中国
推荐引用方式 GB/T 7714	裘涛,陈眉,代建峰,等. 涤痰开窍汤对脑卒中后抑郁大鼠行为能力及脑内神经递质的影响[J],2007,48(8):735-737.
APA	裘涛,陈眉,代建峰,吴乐程,&张宾辉.(2007).涤痰开窍汤对脑卒中后抑郁大鼠行为能力及脑内神经递质的影响.,48(8),735-737.
MLA	裘涛,et al."涤痰开窍汤对脑卒中后抑郁大鼠行为能力及脑内神经递质的影响".48.8(2007):735-737.