干旱区生态环境知识资源中心(Arid): 对口腔鳞状细胞癌行微波凝固治疗的可行性探讨

Arid

	对口腔鳞状细胞癌行微波凝固治疗的可行性探讨
其他题名	The initial mechanism and effect of microwave coagulation therapy on oral squamous cell carcinoma
	张素欣; 王士杰; 段玉芹; 郭兰涛; 陈中
ISSN	1001-3733
出版年	2007
卷号	23 期号:2 页码:231-234
中文摘要	目的:观察微波凝固疗法(microwave coagulation therapy,MCT)治疗口腔鳞状细胞癌后引起的组织和细胞形态学变化及临床效果,探讨口腔鳞状细胞癌MCT的可行性.方法:实验组选用40 例原发口腔鳞状细胞癌,采用MCT方法治疗原发灶,颈部行舌骨上清扫或全颈淋巴结清扫,手术治疗前后辅以平阳霉素化疗,对照组选用40 例全身与局部情况与实验组类似的口腔癌,原发灶采用手术切除,其余治疗同实验组.2 组标本均于手术当时采集并作光镜、透射电镜观察组织和细胞形态学变化.另随访3 年观察疗效.结果:实验组经MCT治疗后,原发灶处组织病理报告变为变性坏死组织、炎性肉芽样改变、渗出坏死、增生或不典型增生样改变.电镜下可见癌邻近组织处出现大量细胞凋亡现象及肥大细胞.随访3 年MCT组局部复发率低于手术组(P＜0.05).结论:MCT可有效杀灭口腔鳞状细胞癌原发灶,同时诱导邻近组织细胞凋亡和免疫增强来控制肿瘤的局部复发,临床证明对口腔鳞状细胞癌施行MCT有可行性.
英文摘要	To observe the morphologic changes of cancer tissues and cells and clinical effect of microwave coagulation therapy (MCT) on oral squamous cell carcinoma.(OSCC),and then to evaluate the possibility of MCT in OSCC treatment. Methods;Forty OSCC patients were involved. MCT was adopted to the treatment of tumor primary focus,and associated with chemotherapy arid lymphadenectomy of surahyoid region or therapeutic neck dissection. After MCT the tissues were extracted for pathological examination immediately and morphologically observatd by transmission electron microscope(TEM). All patients were received follow-up investigation for 3 years. The therapeutic effects of the two groups were observed and compared. Results;After MCT, the tissues of primary focus showed degenerative and neurotic tissue, inflammatory granulation, exudative necrosis, hyperplasia or atypical hyperplasiu under light microscope. Apoptosis and maslocytes were observed besides the primary focus through TEM. Additionally MCT could protect oral faction, fades and improve survival quality and control local recurrence,which was more advanced than other old method(P<0.05). Conclusions; MCT can favorablely obliterate the primary focus of oral carcinoma, and can control the local recurrence of tumor through evoking apoptosis and enhancing immunity. MCT may be served as a promising way in the treatment of OSCC.
中文关键词	口腔鳞状细胞癌 ; 微波凝固治疗 ; 细胞凋亡
英文关键词	Oral squainous cell carcinoma Microwave coagulation therapyApoplosh
语种	中文
国家	中国
收录类别	CSCD
WOS类目	ONCOLOGY
WOS研究方向	Oncology
CSCD记录号	CSCD:2724042
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/221405
作者单位	河北医科大学第四医院, 050011
推荐引用方式 GB/T 7714	张素欣,王士杰,段玉芹,等. 对口腔鳞状细胞癌行微波凝固治疗的可行性探讨[J],2007,23(2):231-234.
APA	张素欣,王士杰,段玉芹,郭兰涛,&陈中.(2007).对口腔鳞状细胞癌行微波凝固治疗的可行性探讨.,23(2),231-234.
MLA	张素欣,et al."对口腔鳞状细胞癌行微波凝固治疗的可行性探讨".23.2(2007):231-234.