干旱区生态环境知识资源中心(Arid): 非小细胞肺癌脑转移瘤治疗方案的优化选择

Arid

	非小细胞肺癌脑转移瘤治疗方案的优化选择
其他题名	Selection of optimal treatment scheme for brain metastases of non-small cell lung cancer
	董明新; 赵彤; 黄京子; 余淑坤; 冯燕; 田中成; 金香顺; 全吉钟; 刘金; 王冬旭
ISSN	0254-5098
出版年	2006
卷号	26 期号:4 页码:371-373
中文摘要	目的优化选择非小细胞肺癌脑转移瘤的治疗方案.方法 72例均有病理学诊断的住院患者.随机分成3组.全颅外放疗组24例(Ⅰ组).伽玛刀加全颅放疗组22例(Ⅱ组).伽玛刀加全颅放疗联合Vm-26治疗组26例(Ⅲ组).全脑外放疗中心剂量36～41 Gy,常规分割4～5周完成.伽玛刀治疗以50%等中心剂量曲线严格覆盖肿瘤边缘,处方剂量16～25 Gy,平均16 Gy.化疗:于全颅放疗DT19-29 Gy,2～3周后,加Vm-26化疗,60 mg·m2·d-1,连用3 d,21 d为1周期,共用2个周期.化疗期间继续放疗.结果 Ⅰ、Ⅱ和Ⅲ组的中位生存时间分别为6.0(1.2～19.0)、9.2(4.4～30.0)和10.8(5.2～42.2)个月,1、2年生存率分别为34.6%和12.6%;62.2%和30.2%;70.8%和35.6%.结论采用3种不同方法治疗非小细胞肺癌脑转移瘤,Ⅲ组在提高局部控制率、延长生存期上明显优于Ⅰ组和Ⅱ组,且毒副作用可耐受.
英文摘要	Objective To select the optimal treatment scheme for brain metastasea of non-small cell lung cancers (NSCI.CK). Methods Seventy-two NSCLC cases diagnosesd by pathology with brain metastases were randomly classified into three groups, Group I , 24 cases with whole brain conventional external fractioned irradiulion of I)T 36-41 Gy/4-5 w, Group II , 22 cases with Y-knife treatment plus whole brain conventional external fractioned irradiation, and Group 111 , 26 oases with y-knife plus whole brain conventional external fractioned irradiation in combination with chemotherapy of Vm-26. The surrounding area of tumor was strictly covered with 50% para-central-dosal curve in y-knife treatment (DT 16-25 Gy wilh a mean of 16 Gy) . The mult-leaf collimulor was selected according to the volume of tumors. Chemotherapy of Vm-26 (60 mg/m2 dl-3) was applied during the treatment with whole brain conventional external fractioned irradiation (I)T 19-29 Gy/2-3 w) , 21 days in a period, 2 periods in total. Results The median survival time was estimated to be 6.0 months (ranged from 1.2 lo 19.0 months) in the Group 1 , 9.2 months (4.4-30 months) in the Group II , and 10.8 months (5.2-42.2 months) in the Group III . The 1-year and 2-year survival rates were 34.6% and 12.6% , 62.2% and 30.2%, and 70.8% and 35.6% respectively in Group 1 , Group II , and Group III, respectively, Conclusion For brain melaslases of NSCLC, y-knife plus whole brain conventional external fractioned irradiation combined with treatment of Vm-26 had a significantly beneficial influence on improvement of the locul control and 1-year and 2-year survival. There was no complaint about the side-effects of the treatment.
中文关键词	脑转移瘤 ; Vm-26化疗 ; 伽玛刀
英文关键词	Brain metastases Chemotherapy of Vm-26 Gamma knife
语种	中文
国家	中国
收录类别	CSCD
WOS类目	MEDICINE GENERAL INTERNAL
WOS研究方向	General & Internal Medicine
CSCD记录号	CSCD:2417842
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/220544
作者单位	北华大学第二临床医院(吉化集团总医院)肿瘤治疗中心, 吉林 132022, 中国
推荐引用方式 GB/T 7714	董明新,赵彤,黄京子,等. 非小细胞肺癌脑转移瘤治疗方案的优化选择[J],2006,26(4):371-373.
APA	董明新.,赵彤.,黄京子.,余淑坤.,冯燕.,...&王冬旭.(2006).非小细胞肺癌脑转移瘤治疗方案的优化选择.,26(4),371-373.
MLA	董明新,et al."非小细胞肺癌脑转移瘤治疗方案的优化选择".26.4(2006):371-373.