干旱区生态环境知识资源中心(Arid): 卡维地洛对不稳定性心绞痛患者血管内皮功能及炎症标志物的影响

Arid

	卡维地洛对不稳定性心绞痛患者血管内皮功能及炎症标志物的影响
其他题名	The Effects of Carvedilol on the Endothelial Function and Inflammation Markers in Patients With Unstable Angina Pectoris
	郑卫星; 盖晓波; 章文莉; 李慧忠
ISSN	1000-3614
出版年	2006
卷号	21 期号:6 页码:412-415
中文摘要	目的:观察卡维地洛对不稳定性心绞痛患者血管内皮功能及炎症标志物的影响.方法:采用随机、对照和单盲方法将86例不稳定性心绞痛患者分为常规治疗组(n=43)和卡维地洛组(n=43).疗程均为4周.治疗过程中有6例被剔除,其中常规治疗组4例,卡维地洛组2例.正常组(20例)不予任何治疗.治疗前后分别采用高分辨率血管超声检测肱动脉血流介导性舒张功能变化,测定血中高敏C反应蛋白(hsCRP)、肿瘤坏死因子-alpha(TNF-alpha)、白细胞介素-6(IL-6)含量.结果:①不稳定性心绞痛患者肱动脉血流介导性舒张功能较正常人明显减弱[(5.82.7)%比(13.83.6)%,P＜0.001],hS-CRP、TNF-alpha及IL-6水平明显高于正常组(P均＜0.01).②常规治疗组和卡维地洛组治疗前肱动脉血流介导性舒张功能无显著差异.治疗后卡维地洛组肱动脉血流介导性舒张功能明显增强,与治疗前比较有非常显著性差异[(5.72.1)%比(8.61.8)%,P＜0.001],而常规治疗组治疗前后无明显变化.治疗后肱动脉血流介导性舒张功能增强与hsCRP、TNF-alpha、IL-6含量减少具有明显相关性(r=-0.68、-0.62、-0.65,P均＜0.01).③卡维地洛治疗后血中hsCRP、TNF-alpha、IL-6含量均显著降低(P均＜0.01),而常规治疗前后则无明显差异(P均＞0.05).结论:不稳定性心绞痛患者的血管内皮损伤与炎症具有密切关系.卡维地洛对不稳定性心绞痛患者具有明显的改善内皮功能作用和抗炎效应.抗炎作用可能是卡维地洛重要的药理作用之一.
英文摘要	Objective: To observe the effects of carvedilol on the endothelial function and inflammation markers in patients with unstable angina pectoris (UAP).Methods: Eighty-six cases with UAP were divided into routine treatment group (group A, n=43) and carvedilol group (group B, n =43) in a randomized, controlled and single blind trial. During trial, 6 oases were rejected. A healthy control group was set up (n =20). Before and after the treatment course, the high sensitive C-reactive protein(hsCRP), tumor necroses factor-alpha(TNF-alpha) and inlerleukin-6(IL-6) of plasma were assayed. The flow-mediated dilatation (FMD) function in brachial artery was measured by high-resolution ultrasound.Results: (1)In UAP patients, the artery FMD function was significantly reduced comparing to the health[(5.8 2.7)% vs. (13.8 3.6) % ,P < 0.001] , as well as concentration of hsCRP, TNF-alpha and IL-6 significantly increased (P < 0.01). (2)Before treatment FMD function in group A was not different from that of group B. FMD function After treatment in group A was markedly increased than that before treatment (8.6 1.8) % vs. (5.7 2.1) % ,P <0.001],but there was no apparent change in group B(P >0.05). The enhancement of FMD function correlated markedly with decreases of hsCRP, TNF-alpha and IL-6 (r = -0.68、-0. 62, -0.65, P <0.01). (3)After treatment, the levels of hsCRP, TNF-alpha and IL-6 decreased apparently (P <0.01), however, no change was observed in B group(P > 0.05 ). Conclusion: The endothelial dysfunction related closely with inflammation in UAR Carvedilol can enhance endothelial function and decrease plasma inflammation marker level of UAR Anti-inflammation mechanism may be one of the key pharmaceutical actions of carvedilol.
中文关键词	不稳定性心绞痛 ; 卡维地洛 ; 内皮功能 ; 炎症标志物
英文关键词	Unstable angina pectoris Carvedilol Endothelial function Inflammation markers
语种	中文
国家	中国
收录类别	CSCD
WOS类目	MEDICINE GENERAL INTERNAL
WOS研究方向	General & Internal Medicine
CSCD记录号	CSCD:2664891
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/220518
作者单位	中国人民解放军南京军区福州总医院,心内科, 福州, 福建 350025, 中国
推荐引用方式 GB/T 7714	郑卫星,盖晓波,章文莉,等. 卡维地洛对不稳定性心绞痛患者血管内皮功能及炎症标志物的影响[J],2006,21(6):412-415.
APA	郑卫星,盖晓波,章文莉,&李慧忠.(2006).卡维地洛对不稳定性心绞痛患者血管内皮功能及炎症标志物的影响.,21(6),412-415.
MLA	郑卫星,et al."卡维地洛对不稳定性心绞痛患者血管内皮功能及炎症标志物的影响".21.6(2006):412-415.