干旱区生态环境知识资源中心(Arid): IL-1RA基因+2018位点突变与矽肺的相关性研究

Arid

	IL-1RA基因+2018位点突变与矽肺的相关性研究
其他题名	Study on association of interleukin-1 receptor antagonist(RA) gene+2018 locus mutation with silicosis
	王德军; 杨跃林; 夏庆杰; 兰亚佳; 王绵珍; 韩吉平; 杨育林; 孔凡玲
ISSN	1000-8020
出版年	2006
卷号	35 期号:6 页码:693-696
中文摘要	目的探讨白细胞介素-1受体拮抗剂基因(IL-1RA)+2018位点突变与中国西南地区汉族人群矽肺易感性的相关性.方法分别选择75名矽肺患者和137名矽尘接触者为研究对象,采集外周静脉血,应用实时荧光定量PCR特异性扩增检测其IL-1RA基因+2018位点突变.结果矽肺组等位基因IL-1RA +2018C的分布频率(28.0%)高于矽尘接触组(15.0%),有统计学差异(P＜0.01);其中Ⅰ期矽肺患者等位基因C的分布频率(31.8%)显著高于矽尘接触组(P＜0.01),而Ⅱ期和Ⅲ期矽肺患者等位基因C的分布频率(22.6%)虽高于矽尘接触组,但无统计学差异(P＜0.01).校正了混杂因素后,Logistic回归分析发现,IL-1RA +2018C的携带者发生矽肺的风险大大增高(P＜0.01).结论 IL-1RA基因+2018位点TC的突变在中国西南地区汉族矽肺发病的遗传因素中起重要作用;IL-1RA可作为研究矽肺易感性的一个侯选基因.
英文摘要	Objective To approach whether + 2018 locus (TC) mutation within the interleukin-1 receptor antagonist (IL-1RA) gene promoter region are associated with susceptibility to silicosis in Southwest Chinese Han population. Methods 75 cases of silicosis and 137 silica-exposed workers (being employed) were selected as subjects. 5ml peripheral vein blood was drawn from each subject. By real-time quantitative polymerase chain reaction and sequencing techniques, IL-1RA gene mutation of all subjects were analyzed. Results The frequency of IL-1RA + 2018C among the oases with silicosis was higher than that among the silica-exposed workers (controls) (28.0% versus 15.0%, Fisher’ s exact P < 0.01). The frequency of allelic C was higher in cases with phase 1 silicosis than in controls (31.8% versus 15.0%, Fisher’s exact P < 0.01). The frequency of allelic C was higher in cases with phase II and HI silicosis than in controls, but which statistic difference being not significant(22.6% versus 15.0%, Fisher’s exact P<0.01). After adjusted for confounding factors, the frequency of IL-1RA + 2018C among silicoscs and its subgroups was still higher than among controls, which statistic difference being significant (Fisher’s exact 0.01). Conclusion IL-1RA gene polymorphisms played an important role in making the Han population of Southwest China susceptible lo silirosis. 1L-IRA might be taked as a gene lo be selected for studing the susceptibility of silieusis.
中文关键词	白细胞介素-1受体拮抗剂 ; 基因突变 ; 矽肺
英文关键词	interleukin-1 receptor antagonist gene mutation silicosis
语种	中文
国家	中国
收录类别	CSCD
WOS类目	PUBLIC ENVIRONMENTAL OCCUPATIONAL HEALTH
WOS研究方向	Public, Environmental & Occupational Health
CSCD记录号	CSCD:2654735
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/220242
作者单位	山东省疾病预防控制中心, 济南, 山东 250014, 中国
推荐引用方式 GB/T 7714	王德军,杨跃林,夏庆杰,等. IL-1RA基因+2018位点突变与矽肺的相关性研究[J],2006,35(6):693-696.
APA	王德军.,杨跃林.,夏庆杰.,兰亚佳.,王绵珍.,...&孔凡玲.(2006).IL-1RA基因+2018位点突变与矽肺的相关性研究.,35(6),693-696.
MLA	王德军,et al."IL-1RA基因+2018位点突变与矽肺的相关性研究".35.6(2006):693-696.