干旱区生态环境知识资源中心(Arid): Accuracy of Estimated Creatinine in Multistage Ultramarathon Runners

Arid

DOI	10.1016/j.wem.2018.12.006
	Accuracy of Estimated Creatinine in Multistage Ultramarathon Runners
	Little, Colin E.1; Lipman, Grant S.2; Migliaccio, Daniel 3; Young, David S.4; Krabak, Brian J.5
通讯作者	Little, Colin E.
来源期刊	WILDERNESS & ENVIRONMENTAL MEDICINE
ISSN	1080-6032
EISSN	1545-1534
出版年	2019
卷号	30 期号:2 页码:129-133
英文摘要	Introduction-Ultramarathon running is increasing in popularity worldwide, as is the growing body of research on these athletes. Multiple studies have examined acute kidney injury through estimated baseline creatinine (Cr) and glomerular filtration rate (GFR). Values are estimated through an age-based formula of GFR and the modification of diet in renal disease (MDRD) equation. However, the accuracy of this practice in a cohort of healthy athletes is unknown. Methods-A prospective analysis of the first 40-km (25-mi) stage of 6-stage 250-km (155-mi) multi-stage ultramarathons in the Sahara, Namibia, Atacama, and Gobi Deserts. Runners had prerace measured baseline Cr compared to estimated values through age-based estimated GFR and back calculation of Cr through the MDRD equation. Results-Forty-eight participants (27% female, age 39 +/- 10 y) had Cr values analyzed. The mean measured Cr was 0.99 +/- 0.17, which was 11% higher than an estimated Cr of 0.88 +/- 0.14 (P<0.01). Estimated age-based GFR was 95.9 +/- 5.8 ml.min(-1) compared to GFR based on measured Cr and MDRD of 86.1 +/- 14.6 (P<0.001). Conclusions-Estimated values of GFR and Cr by standard age-based values and MDRD equation were significantly inaccurate, which would overinflate the incidence of acute kidney injury. Future studies should devise a new model for estimation of baseline Cr that is validated in this population.
英文关键词	acute kidney injury endurance athlete
类型	Article
语种	英语
国家	USA
开放获取类型	Bronze
收录类别	SCI-E
WOS记录号	WOS:000472986100004
WOS关键词	ACUTE KIDNEY INJURY ; EXERCISE-ASSOCIATED HYPONATREMIA ; RENAL-FUNCTION ; HYDRATION STATUS ; CLEARANCE
WOS类目	Public, Environmental & Occupational Health ; Sport Sciences
WOS研究方向	Public, Environmental & Occupational Health ; Sport Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/219328
作者单位	1.Univ Utah, Div Emergency Med, 30 N 1900 E,Suite 1CO26, Salt Lake City, UT 84132 USA; 2.Stanford Dept Emergency Med, Stanford, CA USA; 3.Univ N Carolina, Dept Emergency Med, Chapel Hill, NC 27515 USA; 4.Univ Colorado, Dept Emergency Med, Denver, CO 80202 USA; 5.Univ Washington, Dept Sports Med, Seattle, WA 98195 USA
推荐引用方式 GB/T 7714	Little, Colin E.,Lipman, Grant S.,Migliaccio, Daniel,et al. Accuracy of Estimated Creatinine in Multistage Ultramarathon Runners[J],2019,30(2):129-133.
APA	Little, Colin E.,Lipman, Grant S.,Migliaccio, Daniel,Young, David S.,&Krabak, Brian J..(2019).Accuracy of Estimated Creatinine in Multistage Ultramarathon Runners.WILDERNESS & ENVIRONMENTAL MEDICINE,30(2),129-133.
MLA	Little, Colin E.,et al."Accuracy of Estimated Creatinine in Multistage Ultramarathon Runners".WILDERNESS & ENVIRONMENTAL MEDICINE 30.2(2019):129-133.