干旱区生态环境知识资源中心(Arid): Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer

Arid

DOI	10.3390/toxins11080469
	Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer
	Sirma, Anima J.1; Makita, Kohei 2; Grace Randolph, Delia 3; Senerwa, Daniel 4; Lindahl, Johanna F.3,5,6
通讯作者	Sirma, Anima J.
来源期刊	TOXINS
EISSN	2072-6651
出版年	2019
卷号	11 期号:8
英文摘要	Milk is an important commodity in Kenya; the country has the largest dairy herd and highest per capita milk consumption in East Africa. As such, hazards in milk are of concern. Aflatoxin M-1 (AFM(1)) is a toxic metabolite of aflatoxin B-1 (AFB(1)) excreted in milk by lactating animals after ingesting AFB(1)-contaminated feeds. This metabolite is injurious to human health, but there is little information on the risk to human health posed by AFM(1) in milk in rural Kenya. To fill this gap, a quantitative risk assessment (QRA) applying probabilistic statistical tools to quantify risks was conducted. This assessed the risk of liver cancer posed by AFM(1) in milk, assuming 10-fold lower carcinogenicity than AFB(1). Data from four agro-ecological zones in Kenya (semi-arid, temperate, sub-humid and humid) were used. We estimated that people were exposed to between 0.3 and 1 ng AFM(1) per kg body weight per day through the consumption of milk. The annual incidence rates of cancer attributed to the consumption of AFM(1) in milk were 3.5 x 10(-3) (95% CI: 3 x 10(-3)-3.9 x 10(-3)), 2.9 x 10(-3) (95% CI: 2.5 x 10(-3)-3.3 x 10(-3)), 1.4 x 10(-3) (95% CI: 1.2 x 10(-3)-1.5 x 10(-3)) and 2.7 x 10(-3) (95% CI: 2.3 x 10(-3)-3 x 10(-3)) cancers per 100,000 in adult females, adult males, children 6-18 years old, and in children less than five years old, respectively. Our results show that aflatoxin exposure from milk contributes relatively little to the incidence of liver cancer. Nonetheless, risk managers should take action based on cumulative exposure from all sources of aflatoxins.
英文关键词	mycotoxins risk assessment food safety standards hepatocellular carcinoma East Africa
类型	Article
语种	英语
国家	Kenya ; Japan ; Sweden
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000482994200015
WOS关键词	HEPATOCELLULAR-CARCINOMA ; CONTAMINATION ; MYCOTOXINS ; HEALTH ; FEEDS
WOS类目	Food Science & Technology ; Toxicology
WOS研究方向	Food Science & Technology ; Toxicology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/219112
作者单位	1.Minist Agr Livestock Fisheries & Irrigat Kenya, State Dept Livestock, PO Private Bag Kangemi, Nairobi 00100, Kenya; 2.Rakuno Gakuen Univ, Dept Vet Med, Sch Vet Med, 582 Bunkyodai Midorimachi, Ebetsu, Hokkaido 0698501, Japan; 3.Int Livestock Res Inst, Dept Biosci, POB 30709, Nairobi 00100, Kenya; 4.Univ Nairobi, Dept Publ Hlth & Toxicol, POB 9053, Nairobi 00625, Kenya; 5.Swedish Univ Agr Sci, Dept Clin Sci, POB 7054, SE-75007 Uppsala, Sweden; 6.Uppsala Univ, Dept Med Biochem & Microbiol, POB 582, S-75123 Uppsala, Sweden
推荐引用方式 GB/T 7714	Sirma, Anima J.,Makita, Kohei,Grace Randolph, Delia,et al. Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer[J],2019,11(8).
APA	Sirma, Anima J.,Makita, Kohei,Grace Randolph, Delia,Senerwa, Daniel,&Lindahl, Johanna F..(2019).Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer.TOXINS,11(8).
MLA	Sirma, Anima J.,et al."Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer".TOXINS 11.8(2019).