干旱区生态环境知识资源中心(Arid): Improved determination of femtogram-level organic explosives in multiple matrices using dual-sorbent solid phase extraction and liquid chromatography-high resolution accurate mass spectrometry

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DOI	10.1016/j.talanta.2019.05.047
	Improved determination of femtogram-level organic explosives in multiple matrices using dual-sorbent solid phase extraction and liquid chromatography-high resolution accurate mass spectrometry
	Irlam, Rachel C.1; Parkin, Mark C.1,2; Brabazon, Dermot P.3; Beardah, Matthew S.4; O’Donnell, Michael 4; Barron, Leon P.1
通讯作者	Barron, Leon P.
来源期刊	TALANTA
ISSN	0039-9140
EISSN	1873-3573
出版年	2019
卷号	203 页码:65-76
英文摘要	Identification and trace quantification of multiple explosives residues, their precursors and transformation products in complex samples remains very challenging. For solid phase extraction (SPE) and liquid chromatography-high resolution accurate mass spectrometry-based methods (LC-HRMS), interferences from co-extracted matrix components can significantly affect recovery during extraction and/or detector signal. The aim of this work was to develop a new, improved and more generalisable extraction approach to trace explosives analysis in a range of matrices using dual-sorbent SPE with LC-HRMS. Recoveries of 44 organic explosives from model solutions were optimised and compared for seven different sorbents (Oasis HLB, HyperSep Retain PEP and Isolute ENV +, HyperSep SAX, HyperSep NH2, Strata Alumina-N and Bond Elut CN). On average, Oasis HLB and Isolute ENV + yielded the best recoveries ( > 80%). For three sorbents, mean recoveries remained <= 1%, which made them potentially suitable for matrix removal when used in series with more analyte-selective sorbents. To evaluate matrix effects, a range of aqueous (river- and wastewater), solid (soil), dirty (road sign swabs), oily (oven hood swabs) and biological (dried blood) samples were selected based on complexity and forensic relevance. With the exception of river water, matrix effects were lowest using dual-sorbent SPE, with little/no compromise in recovery. Quantitative method performance assessment is presented for 14 selected explosives, representative of different classes, molecular weights and volatilities, and across three different matrices (i.e. untreated wastewater, cooking oil residues and dried blood). Limits of detection improved by similar to 10-fold over a single sorbent approach, enabling low fg sensitivity in many cases. Finally, application of the method to untreated wastewater enabled detection of new explosives traces for the first time, which could be used to help identify clandestine manufacture or sources of environmental toxicity. This approach offered a versatile solution to sample preparation for robust and highly sensitive detection/quantification of large numbers of explosives residues in a range of complex sample types.
英文关键词	High resolution accurate mass spectrometry Explosives Sample preparation Complex matrices Solid phase extraction
类型	Article
语种	英语
国家	England ; Ireland
开放获取类型	Green Published, Green Submitted, hybrid
收录类别	SCI-E
WOS记录号	WOS:000474319100009
WOS关键词	ELECTRON-CAPTURE DETECTION ; GAS-CHROMATOGRAPHY ; SAMPLE CLEANUP ; TRACE ANALYSIS ; WATER SAMPLES ; PERFORMANCE ; IONIZATION ; RECOVERY ; QUANTIFICATION ; CONTAMINANTS
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
来源机构	University of London
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/219050
作者单位	1.Kings Coll London, Fac Life Sci & Med, Sch Populat Hlth & Environm Sci, Kings Forens, 150 Stamford St, London SE1 9NH, England; 2.Eurofins Forens Serv, Teddington, Middx, England; 3.Dublin City Univ, Adv Proc Technol Res Ctr, Dublin 9, Ireland; 4.Dstl, Forens Explos Lab, Sevenoaks, Kent, England
推荐引用方式 GB/T 7714	Irlam, Rachel C.,Parkin, Mark C.,Brabazon, Dermot P.,et al. Improved determination of femtogram-level organic explosives in multiple matrices using dual-sorbent solid phase extraction and liquid chromatography-high resolution accurate mass spectrometry[J]. University of London,2019,203:65-76.
APA	Irlam, Rachel C.,Parkin, Mark C.,Brabazon, Dermot P.,Beardah, Matthew S.,O’Donnell, Michael,&Barron, Leon P..(2019).Improved determination of femtogram-level organic explosives in multiple matrices using dual-sorbent solid phase extraction and liquid chromatography-high resolution accurate mass spectrometry.TALANTA,203,65-76.
MLA	Irlam, Rachel C.,et al."Improved determination of femtogram-level organic explosives in multiple matrices using dual-sorbent solid phase extraction and liquid chromatography-high resolution accurate mass spectrometry".TALANTA 203(2019):65-76.