干旱区生态环境知识资源中心(Arid): Development and validation of an analytical procedure to detect spatio-temporal differences in antidepressant use through a wastewater-based approach

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DOI	10.1016/j.talanta.2019.03.052
	Development and validation of an analytical procedure to detect spatio-temporal differences in antidepressant use through a wastewater-based approach
	Boogaerts, Tim; Degreef, Maarten; Covaci, Adrian; van Nuijs, Alexander L. N.
通讯作者	Boogaerts, Tim ; van Nuijs, Alexander L. N.
来源期刊	TALANTA
ISSN	0039-9140
EISSN	1873-3573
出版年	2019
卷号	200 页码:340-349
英文摘要	Wastewater-based epidemiology applies the analysis of human metabolic excretion products of xenobiotics in wastewater to estimate the community-wide use of these compounds. A new bioanalytical method was developed, optimised and validated for the analysis of a broad range of antidepressants and their metabolites at trace concentrations in influent wastewater. The assay was based on solid-phase extraction and liquid chromatography coupled to tandem mass spectrometry. For most compounds, Oasis (R) HLB cartridges were used for sample preparation. Oasis (R) MCX cartridges were used for extraction of normirtazapine, moclobemide, sertraline, and melitracen in particular. The Kinetex XBC18 column with a gradient elution resulted in appropriate separation for the analytes under investigation. Validation was done according to the European Medicines Agency guidelines on bioanalytical method validation. For 27 compounds, the performance criteria met the requirements for method validation. For these analytes, the lower limit of quantification (LLOQ) ranged between 1 and 25 ng/L. Furthermore, all targeted biomarkers showed high in-sample stability during 24 h, with the exception of mianserin. The validated assay was applied to influent wastewater samples collected from four wastewater treatment plants in Belgium. Among these four locations, a total of 18 out of 27 biomarkers for antidepressant use were present in the samples in concentrations above the LLOQ. Additionally, the proposed methodology proved capable of analysing high resolution spatio-temporal trends. Mann-Kendall trend analyses showed that antidepressant use is stable throughout the week, except for trazodone which increased throughout the week.
英文关键词	Wastewater-based epidemiology Antidepressants Mass-spectrometric analysis Validation Stability Matrix effects
类型	Article
语种	英语
国家	Belgium
开放获取类型	Green Accepted
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000468715300042
WOS关键词	PRESCRIBED PHARMACEUTICALS ; ILLICIT DRUGS ; EPIDEMIOLOGY ; METABOLITES ; EXPOSURE ; BIOMARKERS ; ALCOHOL ; COCAINE ; ABUSE ; URBAN
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/219048
作者单位	Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium
推荐引用方式 GB/T 7714	Boogaerts, Tim,Degreef, Maarten,Covaci, Adrian,et al. Development and validation of an analytical procedure to detect spatio-temporal differences in antidepressant use through a wastewater-based approach[J],2019,200:340-349.
APA	Boogaerts, Tim,Degreef, Maarten,Covaci, Adrian,&van Nuijs, Alexander L. N..(2019).Development and validation of an analytical procedure to detect spatio-temporal differences in antidepressant use through a wastewater-based approach.TALANTA,200,340-349.
MLA	Boogaerts, Tim,et al."Development and validation of an analytical procedure to detect spatio-temporal differences in antidepressant use through a wastewater-based approach".TALANTA 200(2019):340-349.