干旱区生态环境知识资源中心(Arid): Circulating DNAs, a Marker of Neutrophil Extracellular Traposis and Cancer-Related Stroke: The OASIS-Cancer Study

Arid

DOI	10.1161/STROKEAHA.119.026373
	Circulating DNAs, a Marker of Neutrophil Extracellular Traposis and Cancer-Related Stroke: The OASIS-Cancer Study
	Bang, Oh Young 1,3; Chung, Jong-Won 1,3; Cho, Yeon Hee 3; Oh, Mi Jeong 3; Seo, Woo-Keun 1; Kim, Gyeong-Moon 1; Ahn, Myung-Ju 2
通讯作者	Bang, Oh Young
来源期刊	STROKE
ISSN	0039-2499
EISSN	1524-4628
出版年	2019
卷号	50 期号:10 页码:2944-2947
英文摘要	Background and Purpose-The role of circulating neutrophil extracellular traps (NETs) in cancer-related stroke is unknown. Methods-We conducted a prospective cohort study to test whether NETs are increased in cancer-related stroke and whether elevated NETs levels are associated with coagulopathy, assessed using D-dimer levels (>= 2 mu g/mL). Plasma DNA and nucleosome were assessed as NET-specific biomarkers. Results-In total, 138 patients were recruited; 38 patients had cancer-related stroke (active cancer and acute cryptogenic embolic stroke), 33 patients were healthy-controls, 27 patients were cancer-controls (active cancer but no stroke), and 40 patients were stroke-controls (acute ischemic stroke but no cancer). Plasma DNA and nucleosome levels were significantly elevated in cancer-related stroke patients than in healthy-controls (P<0.05). These levels were correlated with the D-dimer levels (P<0.01). In multiple regression analyses, increased plasma DNA levels were associated with cancer-related stroke (odds ratio=11.65 for highest quartile; 95% CI, 3.199-42.46) and D-dimer levels of >= 2 mu g/mL (odds ratio=19.09 for highest quartile; 95% CI, 4.143-87.95) after adjusting for possible confounders. Conclusions-Increased circulating DNA levels were associated with cancer-related stroke, suggesting that NETosis is one of the molecular mechanisms of cancer-related stroke. Further long-term follow-up studies in large cohorts are needed to confirm the role of NET-specific biomarkers.
英文关键词	biomarkers cancer cerebral stroke extracellular traps nucleosomes plasma thrombosis
类型	Article
语种	英语
国家	South Korea
开放获取类型	Bronze
收录类别	SCI-E
WOS记录号	WOS:000489337300065
WOS关键词	TRAPS
WOS类目	Clinical Neurology ; Peripheral Vascular Disease
WOS研究方向	Neurosciences & Neurology ; Cardiovascular System & Cardiology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/218942
作者单位	1.Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul, South Korea; 2.Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Hematooncol, Seoul, South Korea; 3.Samsung Med Ctr, Translat & Stem Cell Res Lab Stroke, Seoul, South Korea
推荐引用方式 GB/T 7714	Bang, Oh Young,Chung, Jong-Won,Cho, Yeon Hee,et al. Circulating DNAs, a Marker of Neutrophil Extracellular Traposis and Cancer-Related Stroke: The OASIS-Cancer Study[J],2019,50(10):2944-2947.
APA	Bang, Oh Young.,Chung, Jong-Won.,Cho, Yeon Hee.,Oh, Mi Jeong.,Seo, Woo-Keun.,...&Ahn, Myung-Ju.(2019).Circulating DNAs, a Marker of Neutrophil Extracellular Traposis and Cancer-Related Stroke: The OASIS-Cancer Study.STROKE,50(10),2944-2947.
MLA	Bang, Oh Young,et al."Circulating DNAs, a Marker of Neutrophil Extracellular Traposis and Cancer-Related Stroke: The OASIS-Cancer Study".STROKE 50.10(2019):2944-2947.