干旱区生态环境知识资源中心(Arid): Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil

Arid

DOI	10.1038/s41598-019-38789-z
	Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil
	Carro, Lorena 1,2; Castro, Jean Franco 2,3,4; Razmilic, Valeria 2,3; Nouioui, Imen 2; Pan, Che 2; Igual, Jose M.5,6; Jaspars, Marcel 4; Goodfellow, Michael 2; Bull, Alan T.7; Asenjo, Juan A.3; Klenk, Hans-Peter 2
通讯作者	Carro, Lorena
来源期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
出版年	2019
卷号	9
英文摘要	The taxonomic status, biotechnological and ecological potential of several Micromonospora strains isolated from an extreme hyper arid Atacama Desert soil were determined. Initially, a polyphasic study was undertaken to clarify the taxonomic status of five micromonosporae, strains LB4, LB19, LB32(T), LB39(T) and LB41, isolated from an extreme hyper-arid soil collected from one of the driest regions of the Atacama Desert. All of the isolates were found to have chemotaxonomic, cultural and morphological properties consistent with their classification in the genus Micromonospora. Isolates LB32(T) and LB39(T) were distinguished from their nearest phylogenetic neighbours and proposed as new species, namely as Micromonospora arida sp. nov. and Micromonospora inaquosa sp. nov., respectively. Eluted methanol extracts of all of the isolates showed activity against a panel of bacterial and fungal indicator strains, notably against multi-drug resistant Klebsiella pneumoniae ATCC 700603 while isolates LB4 and LB41 showed pronounced anti-tumour activity against HepG2 cells. Draft genomes generated for the isolates revealed a rich source of novel biosynthetic gene clusters, some of which were unique to individual strains thereby opening up the prospect of selecting especially gifted micromonosporae for natural product discovery. Key stress-related genes detected in the genomes of all of the isolates provided an insight into how micromonosporae adapt to the harsh environmental conditions that prevail in extreme hyper-arid Atacama Desert soils.
类型	Article
语种	英语
国家	Spain ; England ; Chile ; Scotland
开放获取类型	gold, Green Accepted, Green Published
收录类别	SCI-E
WOS记录号	WOS:000461415900005
WOS关键词	MULTILOCUS SEQUENCE-ANALYSIS ; SP NOV. ; NATURAL-PRODUCTS ; ROOT-NODULES ; GENE ; BIOSYNTHESIS ; ACTINOMYCETE ; RHIZOSPHERE ; SYSTEMATICS ; ACTIVATION
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/218764
作者单位	1.Univ Salamanca, Microbiol & Genet Dept, Salamanca, Spain; 2.Newcastle Univ, Sch Nat & Environm Sci, Newcastle Upon Tyne, Tyne & Wear, England; 3.Univ Chile, Ctr Biotechnol & Bioengn CeBiB, Dept Chem Engn Biotechnol & Mat, Beauchef 851, Santiago, Chile; 4.Univ Aberdeen, Marine Biodiscovery Ctr, Dept Chem, Aberdeen, Scotland; 5.CSIC, IRNASA, Inst Recursos Nat & Agrobiol Salamanca, Salamanca, Spain; 6.Univ Salamanca, Grp Interacc Planta Microorganismo, Unidad Asociada, CSIC, Salamanca, Spain; 7.Univ Kent Canterbury, Sch Biosci, Canterbury, Kent, England
推荐引用方式 GB/T 7714	Carro, Lorena,Castro, Jean Franco,Razmilic, Valeria,et al. Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil[J],2019,9.
APA	Carro, Lorena.,Castro, Jean Franco.,Razmilic, Valeria.,Nouioui, Imen.,Pan, Che.,...&Klenk, Hans-Peter.(2019).Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil.SCIENTIFIC REPORTS,9.
MLA	Carro, Lorena,et al."Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil".SCIENTIFIC REPORTS 9(2019).