干旱区生态环境知识资源中心(Arid): Plant origin authentication of Sonoran Desert propolis: an antiproliferative propolis from a semi-arid region

Arid

DOI	10.1007/s00114-019-1620-2
	Plant origin authentication of Sonoran Desert propolis: an antiproliferative propolis from a semi-arid region
	Alday, Efrain 1; Valencia, Dora 2; Garibay-Escobar, Adriana 1; Dominguez-Esquivel, Zaira 3; Lisa Piccinelli, Anna 4; Rastrelli, Luca 4; Monribot-Villanueva, Juan 5; Guerrero-Analco, Jose A.5; Enrique Robles-Zepeda, Ramon 1; Hernandez, Javier 3; Velazquez, Carlos 1
通讯作者	Hernandez, Javier ; Velazquez, Carlos
来源期刊	SCIENCE OF NATURE
ISSN	0028-1042
EISSN	1432-1904
出版年	2019
卷号	106 期号:5-6
英文摘要	The main chemical composition of Sonoran propolis (SP), as well as its antiproliferative activity on cancer cells through apoptosis induction, has been reported. The chemical constitution of SP remained qualitatively similar throughout the year, whereas the antiproliferative effect on cancer cells exhibited significant differences amongst seasonal samples. The main goal of this study was to provide phytochemical and pharmacological evidence for the botanical source of SP and its antiproliferative constituents. A chemical comparative analysis of SP and plant resins of species found in the surrounding areas of the beehives was carried out by HPLC-UV-DAD, as well as by H-1 NMR experiments. The antiproliferative activity on cancerous (M12.C3.F6, HeLa, A549, PC-3) and normal cell lines (L-929; ARPE-19) was assessed through MTT assays. Here, the main polyphenolic profile of SP resulted to be qualitatively similar to Populus fremontii resins (PFR). However, the antiproliferative activity of PFR on cancer cells did not consistently match that exhibited by SP throughout the year. Additionally, SP induced morphological modifications on treated cells characterised by elongation, similar to those induced by colchicine, and different to those observed with PFR treatment. These results suggest that P. fremontii is the main botanical source of SP along the year. Nevertheless, the antiproliferative constituents of SP that induce that characteristic morphological elongation on treated cells are not obtained from PFR. Moreover, the presence of kaempferol-3-methyl-ether in SP could point Ambrosia ambrosioides as a secondary plant source. In conclusion, SP is a bioactive poplar-type propolis from semi-arid zones, in which chemical compounds derived from other semi-arid plant sources than poplar contribute to its antiproliferative activity.
英文关键词	Sonoran Desert propolis Polyphenolic profile Populus fremontii S Watson Ambrosia ambrosioides (Cav.)Payne Antiproliferative activity
类型	Article
语种	英语
国家	Mexico ; Italy
收录类别	SCI-E
WOS记录号	WOS:000467697400003
WOS关键词	CHEMICAL-COMPOSITION ; ANTIOXIDANT ACTIVITY ; BIOLOGICAL-PROPERTIES ; BRAZILIAN PROPOLIS ; HONEY-BEES ; ANTIBACTERIAL ; TOXICITY
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/218573
作者单位	1.Univ Sonora, Dept Chem Biol, Blvd Luis Encinas & Rosales S-N, Hermosillo 83000, Sonora, Mexico; 2.Univ Sonora, Dept Chem Biol & Agropecuary Sci, Av Univ & Irigoyen, Caborca 83600, Son, Mexico; 3.Univ Veracruzana, Unidad Serv Apoyo Resoluc Analit, Lab Quim Prod Nat, Dr Luis Castelazo Ayala S-N 575, Xalapa 91190, Veracruz, Mexico; 4.Univ Salerno, Dipartimento Farm, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy; 5.Cluster Cient & Tecnol Biomimic, Inst Ecol INECOL AC, Red Estudios Mol Avanzados, Carretera Antigua Coatepec 351, Xalapa 91070, Veracruz, Mexico
推荐引用方式 GB/T 7714	Alday, Efrain,Valencia, Dora,Garibay-Escobar, Adriana,et al. Plant origin authentication of Sonoran Desert propolis: an antiproliferative propolis from a semi-arid region[J],2019,106(5-6).
APA	Alday, Efrain.,Valencia, Dora.,Garibay-Escobar, Adriana.,Dominguez-Esquivel, Zaira.,Lisa Piccinelli, Anna.,...&Velazquez, Carlos.(2019).Plant origin authentication of Sonoran Desert propolis: an antiproliferative propolis from a semi-arid region.SCIENCE OF NATURE,106(5-6).
MLA	Alday, Efrain,et al."Plant origin authentication of Sonoran Desert propolis: an antiproliferative propolis from a semi-arid region".SCIENCE OF NATURE 106.5-6(2019).