干旱区生态环境知识资源中心(Arid): Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor

Arid

DOI	10.1126/sciadv.aav5495
	Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor
	Wei, Jianing 1; Shao, Wenbo 1,2; Cao, Minmin 1,3; Ge, Jin 1,3; Yang, Pengcheng 1,2; Chen, Li 1; Wang, Xianhui 1; Kang, Le 1,2,3
通讯作者	Wang, Xianhui ; Kang, Le
来源期刊	SCIENCE ADVANCES
ISSN	2375-2548
出版年	2019
卷号	5 期号:1
英文摘要	Many aggregating animals use aposematic signals to advertise their toxicity to predators. However, the coordination between aposematic signals and toxins is poorly understood. Here, we reveal that phenylacetonitrile (PAN) acts as an olfactory aposematic signal and precursor of hypertoxic hydrogen cyanide (HCN) to protect gregarious locusts from predation. We found that PAN biosynthesis from phenylalanine is catalyzed by CYP305M2, a novel gene encoding a cytochrome P450 enzyme in gregarious locusts. The RNA interference (RNAi) knockdown of CY-P305M2 increases the vulnerability of gregarious locusts to bird predation. By contrast, the elevation of PAN levels through supplementation with synthetic PAN increases the resistance of solitary locusts to predation. When locusts are attacked by birds, PAN is converted to HCN, which causes food poisoning in birds. Our results indicate that locusts develop a defense mechanism wherein an aposematic compound is converted to hypertoxic cyanide in resistance to predation by natural enemies.
类型	Article
语种	英语
国家	Peoples R China
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000457547900062
WOS关键词	HERBIVORE-INDUCED PHENYLACETONITRILE ; GREGARIA FORSKAL ORTHOPTERA ; SCHISTOCERCA-GREGARIA ; DESERT LOCUST ; CYTOCHROME-P450 ENZYMES ; L-PHENYLALANINE ; GIANT KNOTWEED ; AGGREGATION ; PHEROMONE ; BIOSYNTHESIS
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/218549
作者单位	1.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing 100080, Peoples R China; 2.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wei, Jianing,Shao, Wenbo,Cao, Minmin,et al. Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor[J],2019,5(1).
APA	Wei, Jianing.,Shao, Wenbo.,Cao, Minmin.,Ge, Jin.,Yang, Pengcheng.,...&Kang, Le.(2019).Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor.SCIENCE ADVANCES,5(1).
MLA	Wei, Jianing,et al."Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor".SCIENCE ADVANCES 5.1(2019).