干旱区生态环境知识资源中心(Arid): Anti-inflammatory potency of Locusta migratoria manilensis cyclopeptides in mast cells and macrophages

Arid

DOI	10.1039/c9ra06284j
	Anti-inflammatory potency of Locusta migratoria manilensis cyclopeptides in mast cells and macrophages
	Liu, Jie 1,2; Wang, Huailing 1,2; Wang, Guangjun 3; Luo, Qiang 2; Cao, Hui 2; Liu, Xiaoyu 2; Zhang, Zehuang 3; Yang, Pingchang 2; Liu, Zhigang 1,2
通讯作者	Liu, Zhigang
来源期刊	RSC ADVANCES
EISSN	2046-2069
出版年	2019
卷号	9 期号:54 页码:31296-31305
英文摘要	Locusts are esteemed as a traditional Chinese medicine, as well as tonic foods in Asian countries. While searching for natural anti-inflammatory agents in natural products, we isolated four novel locust cyclopeptides (LCPs) and the results show that [cyclo-(Trp-Leu-His-Thr)]similar to LCP-3 has potent anti-inflammatory potency in RAW264.7 and HMC-1 cells under LPS (lipopolysaccharide) stimuli. Furthermore, mechanistic studies show that LCP-3 attenuates pro-inflammatory cytokine (TNF-alpha, IL-6, IL-1 beta, NO and PGE2) expression. Moreover, LCP-3 attenuates inflammatory damage associated with the direct inhibition of iNOS and COX-2 expression. LCP-3 also regulates the MAPK, PI3K/AKT and NF-kappa B pathways to attenuate LPS-induced damage. Of note, our study first reports the anti-inflammatory potency of LCPs and elucidates their underlying molecular mechanisms.
类型	Article
语种	英语
国家	Peoples R China
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000490283500013
WOS关键词	NF-KAPPA-B ; CYCLIC-PEPTIDES ; DESERT LOCUST ; INFLAMMATION ; INHIBITION ; ANTIFUNGAL ; ACTIVATION ; INDUCTION ; ALPHA
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/218527
作者单位	1.Shenzhen Univ, Affiliated Hosp 3, Shenzhen 518020, Peoples R China; 2.Shenzhen Univ, Res Ctr Allergy & Immunol, Sch Med, Shenzhen 518060, Peoples R China; 3.Chinese Acad Agr Sci, Inst Plant Protect, Beijing 100193, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jie,Wang, Huailing,Wang, Guangjun,et al. Anti-inflammatory potency of Locusta migratoria manilensis cyclopeptides in mast cells and macrophages[J],2019,9(54):31296-31305.
APA	Liu, Jie.,Wang, Huailing.,Wang, Guangjun.,Luo, Qiang.,Cao, Hui.,...&Liu, Zhigang.(2019).Anti-inflammatory potency of Locusta migratoria manilensis cyclopeptides in mast cells and macrophages.RSC ADVANCES,9(54),31296-31305.
MLA	Liu, Jie,et al."Anti-inflammatory potency of Locusta migratoria manilensis cyclopeptides in mast cells and macrophages".RSC ADVANCES 9.54(2019):31296-31305.