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| DOI | 10.1097/IAE.0000000000001982 |
| THE OASIS MP-1 SUBSTUDY Characterization of the Effect of Ocriplasmin on Microperimetry Parameters | |
| Sadda, Srinivas R.1; Dugel, Pravin U.2,3,4; Gonzalez, Victor H.5; Meunier, Esmeralda6; Kozma, Petra6 | |
| 通讯作者 | Sadda, Srinivas R. |
| 来源期刊 | RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
 |
| ISSN | 0275-004X |
| EISSN | 1539-2864 |
| 出版年 | 2019 |
| 卷号 | 39期号:2页码:319-330 |
| 英文摘要 | Purpose: To evaluate the effects of ocriplasmin and symptomatic vitreomacular adhesion resolution on visual fixation and macular sensitivity using microperimetry. Methods: MP-1 parameters were analyzed from 3 OASIS sites after the use of standardized instruments and testing procedures over 24 months. Results: A total of 27 patients (19 ocriplasmin, 8 sham) were evaluated. Mean distance of the preferred fixation locus to the anatomical center was farther in the sham group at baseline and farther in the sham versus ocriplasmin group throughout the study. Retinal sensitivity values were consistently higher in the ocriplasmin versus sham group after Month 3. Fewer patients in the ocriplasmin group had predominantly eccentric fixation at study end compared with the sham group, which also had an increased number of patients with unstable fixation. Patients with vitreomacular adhesion resolution had lower bivariate contour area, fewer relative scotomas, and higher retinal sensitivity parameters at baseline than those with unresolved vitreomacular adhesion. Conclusion: Substudy results suggest that fixation and sensitivity parameters tended to be better in the ocriplasmin group than in the sham group over time. The substudy identified parameters that were distinct between patients with and without vitreomacular adhesion resolution, suggesting that microperimetry warrants further study as a relevant biomarker for visual function. |
| 英文关键词 | microperimetry ocriplasmin visual function vitreomacular traction |
| 类型 | Article |
| 语种 | 英语 |
| 国家 | USA ; Belgium |
| 开放获取类型 | Green Published, hybrid |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000480739100013 |
| WOS关键词 | PREFERRED RETINAL LOCI ; VITREOMACULAR TRACTION ; INTRAVITREAL OCRIPLASMIN ; MACULAR HOLE |
| WOS类目 | Ophthalmology |
| WOS研究方向 | Ophthalmology |
| 来源机构 | University of California, Los Angeles |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/218467 |
| 作者单位 | 1.Univ Calif Los Angeles, Doheny Eye Inst, Los Angeles, CA USA; 2.Univ Southern Calif, Keck Sch Med, USC Roski Eye Inst, Los Angeles, CA 90033 USA; 3.Retinal Res Inst LLC, Retinal Consultants Arizona LTD, Phoenix, AZ USA; 4.Banner Univ, Med Ctr, Phoenix Eye Inst, Phoenix, AZ USA; 5.Valley Retina Inst PA, Mcallen, TX USA; 6.ThromboGenics NV, Leuven, Belgium |
| 推荐引用方式 GB/T 7714 | Sadda, Srinivas R.,Dugel, Pravin U.,Gonzalez, Victor H.,et al. THE OASIS MP-1 SUBSTUDY Characterization of the Effect of Ocriplasmin on Microperimetry Parameters[J]. University of California, Los Angeles,2019,39(2):319-330. |
| APA | Sadda, Srinivas R.,Dugel, Pravin U.,Gonzalez, Victor H.,Meunier, Esmeralda,&Kozma, Petra.(2019).THE OASIS MP-1 SUBSTUDY Characterization of the Effect of Ocriplasmin on Microperimetry Parameters.RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,39(2),319-330. |
| MLA | Sadda, Srinivas R.,et al."THE OASIS MP-1 SUBSTUDY Characterization of the Effect of Ocriplasmin on Microperimetry Parameters".RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 39.2(2019):319-330. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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