干旱区生态环境知识资源中心(Arid): Gulf War illness associated with abnormal auditory P1 event-related potential: Evidence of impaired cholinergic processing replicated in a national sample

Arid

DOI	10.1016/j.pscychresns.2018.11.006
	Gulf War illness associated with abnormal auditory P1 event-related potential: Evidence of impaired cholinergic processing replicated in a national sample
	Tillman, Gail D.1; Spence, Jeffrey S.2; Briggs, Richard W.3; Haley, Robert W.2; Hart, John, Jr.1,4; Kraut, Michael A.1,5
通讯作者	Hart, John, Jr.
来源期刊	PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN	0925-4927
EISSN	1872-7506
出版年	2019
卷号	283 页码:7-15
英文摘要	Our team previously reported event-related potential (ERP) and hyperarousal patterns from a study of one construction battalion of the U.S. Naval Reserve who served during the 1991 Persian Gulf War. We sought to replicate these findings in a sample that was more representative of the entire Gulf War-era veteran population, including male and female participants from four branches of the military. We collected ERP data from 40 veterans meeting Haley criteria for Gulf War syndromes 1-3 and from 22 matched Gulf War veteran controls while they performed an auditory oddball task. Reports of hyperarousal from the ill veterans were significantly greater than those from the control veterans, and P1 amplitudes in Syndromes 2 and 3 were significantly higher than P1 amplitudes in Syndrome 1, replicating our previous findings. Many of the contributors to the generation of the P1 potential are also involved in the regulation of arousal and are modulated by cholinergic and dopaminergic systems-two systems whose dysfunction has been implicated in Gulf War illness. These differences among the three syndrome groups where their means were on either side of controls is a replication of our previous ERP study and is consistent with previous imaging studies of this population.
英文关键词	Hyperarousal ERP Dopaminergic Desert storm Desert shield Neurotoxic
类型	Article
语种	英语
国家	USA
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000458614700002
WOS关键词	POSTTRAUMATIC-STRESS-DISORDER ; CHEMICAL WEAPONS FALLOUT ; LONG-DISTANCE TRANSIT ; PYRIDOSTIGMINE BROMIDE ; BASOLATERAL AMYGDALA ; SENSORIMOTOR DEFICIT ; CASE-DEFINITION ; VETERANS ; P50 ; MODULATION
WOS类目	Clinical Neurology ; Neuroimaging ; Psychiatry
WOS研究方向	Neurosciences & Neurology ; Psychiatry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/218196
作者单位	1.Univ Texas Dallas, Ctr BrainHlth, Dallas, TX 75235 USA; 2.Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX USA; 3.Univ Texas Southwestern Med Ctr Dallas, Dept Radiol, Dallas, TX USA; 4.Univ Texas Southwestern Med Ctr Dallas, Dept Neurol, Dallas, TX USA; 5.Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21205 USA
推荐引用方式 GB/T 7714	Tillman, Gail D.,Spence, Jeffrey S.,Briggs, Richard W.,et al. Gulf War illness associated with abnormal auditory P1 event-related potential: Evidence of impaired cholinergic processing replicated in a national sample[J],2019,283:7-15.
APA	Tillman, Gail D.,Spence, Jeffrey S.,Briggs, Richard W.,Haley, Robert W.,Hart, John, Jr.,&Kraut, Michael A..(2019).Gulf War illness associated with abnormal auditory P1 event-related potential: Evidence of impaired cholinergic processing replicated in a national sample.PSYCHIATRY RESEARCH-NEUROIMAGING,283,7-15.
MLA	Tillman, Gail D.,et al."Gulf War illness associated with abnormal auditory P1 event-related potential: Evidence of impaired cholinergic processing replicated in a national sample".PSYCHIATRY RESEARCH-NEUROIMAGING 283(2019):7-15.