Knowledge Resource Center for Ecological Environment in Arid Area
| DOI | 10.1371/journal.pone.0216679 |
| Seasonal adaptations of the hypothalamo-neurohypophyseal system of the dromedary camel | |
| Alim, Fatma Zohra Djazouli1,2; Romanova, Elena V.3,4; Tay, Yea-Ling5; Rahman, Ahmad Yamin bin Abdul5; Chan, Kok-Gan6,7; Hong, Kar-Wai7; Rogers, Mark8; Southey, Bruce R.9; Greenwood, Michael P.10; Mecawi, Andre Souza11,12,13; Mustafa, Mohammad Rais14; Mahy, Nicole15,16; Campbell, Colin8; Antunes-Rodrigues, Jose13; Sweedler, Jonathan V.3,4; Murphy, David10,12; Hindmarch, Charles C. T.10,12,17 | |
| 通讯作者 | Alim, Fatma Zohra Djazouli ; Hindmarch, Charles C. T. |
| 来源期刊 | PLOS ONE
 |
| ISSN | 1932-6203 |
| 出版年 | 2019 |
| 卷号 | 14期号:6 |
| 英文摘要 | The ship of the Arabian and North African deserts, the one-humped dromedary camel (Camelus dromedarius) has a remarkable capacity to survive in conditions of extreme heat without needing to drink water. One of the ways that this is achieved is through the actions of the antidiuretic hormone arginine vasopressin (AVP), which is made in a specialised part of the brain called the hypothalamo-neurohypophyseal system (HNS), but exerts its effects at the level of the kidney to provoke water conservation. Interestingly, our electron microscopy studies have shown that the ultrastructure of the dromedary HNS changes according to season, suggesting that in the arid conditions of summer the HNS is in an activated state, in preparation for the likely prospect of water deprivation. Based on our dromedary genome sequence, we have carried out an RNAseq analysis of the dromedary HNS in summer and winter. Amongst the 171 transcripts found to be significantly differentially regulated (>2 fold change, p value <0.05) there is a significant over-representation of neuropeptide encoding genes, including that encoding AVP, the expression of which appeared to increase in summer. Identification of neuropeptides in the HNS and analysis of neuropeptide profiles in extracts from individual camels using mass spectrometry indicates that overall AVP peptide levels decreased in the HNS during summer compared to winter, perhaps due to increased release during periods of dehydration in the dry season. |
| 类型 | Article |
| 语种 | 英语 |
| 国家 | Algeria ; USA ; Malaysia ; Peoples R China ; England ; Brazil ; Spain ; Canada |
| 开放获取类型 | Green Submitted, Green Published, gold |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000484891700005 |
| WOS关键词 | MEDIAN PREOPTIC NUCLEUS ; BLOOD-BRAIN-BARRIER ; SUPRAOPTIC NUCLEUS ; MAGNOCELLULAR NUCLEI ; RAT HYPOTHALAMUS ; MICROGLIA ; WATER ; VASOPRESSIN ; OXYTOCIN ; NEURONS |
| WOS类目 | Multidisciplinary Sciences |
| WOS研究方向 | Science & Technology - Other Topics |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/218113 |
| 作者单位 | 1.Fac Nat & Life Sci, Dept Biotechnol, Route Soumaa Blida, Bejaia, Algeria; 2.Normale Super Sch Kouba, Lab Anim Ecobiol LEBA, Bachir El Ibrahimi, Algeria; 3.Univ Illinois, Dept Chem, Urbana, IL USA; 4.Univ Illinois, Beckman Inst, Urbana, IL USA; 5.BioEasy Sdn Bhd, Shah Alam, Selangor Darul, Malaysia; 6.Jiangsu Univ, Int Genome Ctr, Zhenjiang, Jiangsu, Peoples R China; 7.Univ Malaya, Fac Sci, Inst Biol Sci, Div Genet & Mol Biol, Kuala Lumpur, Malaysia; 8.Univ Bristol, Dept Engn Math, Merchant Venturers Buliding, Bristol, Avon, England; 9.Univ Illinois, Dept Anim Sci, Anim Sci Lab, Urbana, IL USA; 10.Univ Bristol, Sch Clin Sci, Dorothy Hodgkin Bldg, Bristol, Avon, England; 11.Univ Fed Rural Rio de Janeiro, Inst Biol & Hlth Sci, Dept Physiol Sci, Seropedica, RJ, Brazil; 12.Univ Malaya, Dept Physiol, Fac Med, Kuala Lumpur, Malaysia; 13.Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Physiol, Ribeirao Preto, SP, Brazil; 14.Univ Malaya, Dept Pharmacol, Fac Med, Kuala Lumpur, Malaysia; 15.Univ Barcelona, IDIBAPS, Dept Biomed, Barcelona, Spain; 16.Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain; 17.Queens Univ, Dept Med, Translat Inst Med TIME, Queens Cardiopulm Unit QCPU, Kingston, ON, Canada |
| 推荐引用方式 GB/T 7714 | Alim, Fatma Zohra Djazouli,Romanova, Elena V.,Tay, Yea-Ling,et al. Seasonal adaptations of the hypothalamo-neurohypophyseal system of the dromedary camel[J],2019,14(6). |
| APA | Alim, Fatma Zohra Djazouli.,Romanova, Elena V..,Tay, Yea-Ling.,Rahman, Ahmad Yamin bin Abdul.,Chan, Kok-Gan.,...&Hindmarch, Charles C. T..(2019).Seasonal adaptations of the hypothalamo-neurohypophyseal system of the dromedary camel.PLOS ONE,14(6). |
| MLA | Alim, Fatma Zohra Djazouli,et al."Seasonal adaptations of the hypothalamo-neurohypophyseal system of the dromedary camel".PLOS ONE 14.6(2019). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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