干旱区生态环境知识资源中心(Arid): Association between vitamin D deficiency and allergic symptom in pregnant women

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DOI	10.1371/journal.pone.0214797
	Association between vitamin D deficiency and allergic symptom in pregnant women
	Kanatani, Kumiko T.1,2,9; Adachi, Yuichi 3,10; Hamazaki, Kei 4,10; Onishi, Kazunari 5,11; Go, Tohshin 2,9; Hirabayashi, Kyoko 2,9; Watanabe, Motonobu 6,9; Sato, Keiko 2,7,9; Kurozawa, Youichi 5,11; Inadera, Hidekuni 4,10; Oyama, Hiroshi 8; Nakayama, Takeo 1,9; Konishi, Ikuo 9; Heike, Toshio 9; Konishi, Yukuo 9; Egawa, Miho 9; Takahashi, Yoshimitsu 9; Yasumi, Reiko 9; Morita, Masahito 9; Konishi, Kaori 9; Tsuchida, Akiko 10; Fukumoto, Soji 11; Teshima, Ryota 11; Inoue, Takao 11; Harada, Tasuku 11; Kanzaki, Susumu 11; Maegaki, Yoshihiro 11; Ohno, Kosaku 11; Koeda, Tatsuya 11; Masumoto, Toshio 11
通讯作者	Kanatani, Kumiko T.
来源期刊	PLOS ONE
ISSN	1932-6203
出版年	2019
卷号	14 期号:4
英文摘要	Background Vitamin D has been reported to affect both innate, and acquired immunity with immune cells such as dendritic cells having the vitamin D receptors. The co-occurrence of the high prevalence of allergic diseases and vitamin D deficiency globally documented in recent decades, has prompted a hypothesis on whether there is a reasonable association between them. Objective To investigate the association between serum vitamin D deficiency and allergic symptoms. Methods Historical cohort. On a cohort study for the association between desert dust exposure and allergic symptoms in 3,327 pregnant women during spring and fall in 2011-2013 in Japan conducted as an adjunct study to the Japan Environment and Children's Study, we promptly acquired subjects' daily allergic symptom scores by sending a web-based questionnaire to each participant on some days. Of the 29,434 answers provided by 3,327 participating pregnant women, we extracted 13,356 answers from 1,475 pregnant women that were answered within a 3-month period after blood samplings. And we measured 25(OH) D levels on those samples to investigate the association between their vitamin D deficiency (serum 25(OH)D < 20ng/mL) and the occurrence of any allergic symptom (allergic symptom score> 0) within 3 months. Results Serum 25(OH)D was less than 20ng/mL in 1,233 of 1,745 samples (70.7%). The adjusted odds ratio (aOR) for occurrence of any allergic symptom in deficient cases compared with non-deficient cases was 1.33 (95% CI: 1.07-1.64, p = 0.01). Further, vitamin D deficiency significantly enhanced the risk increase at desert dust events and at pollen exposure (p-values for interaction <0.1). Conclusion We confirmed the association between serum vitamin D deficiency and allergic symptoms in Japanese pregnant women.
类型	Article
语种	英语
国家	Japan
开放获取类型	gold, Green Published, Green Submitted
收录类别	SCI-E
WOS记录号	WOS:000463992600035
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/218096
作者单位	1.Kyoto Univ, Sch Publ Hlth, Dept Hlth Informat, Kyoto, Japan; 2.Kyoto Univ, Grad Sch Med, Kyoto Unit Ctr Japan Environm & Childrens Study, Kyoto, Japan; 3.Univ Toyama, Fac Med, Dept Pediat, Toyama, Japan; 4.Univ Toyama, Dept Publ Hlth, Toyama, Japan; 5.Tottori Univ, Dept Publ Hlth, Yonago, Tottori, Japan; 6.Doshisha Univ, Ctr Baby Sci, Kyoto, Japan; 7.Kyoto Univ Hosp, Inst Adv Clin & Translat Sci, Kyoto, Japan; 8.Univ Tokyo, Grad Sch Med, Sch Publ Hlth, Dept Clin Informat Engn,Hlth Serv Sci, Tokyo, Japan; 9.Kyoto Reg Ctr, Kyoto, Japan; 10.Toyama Reg Ctr, Toyama, Japan; 11.Tottori Reg Ctr, Tottori, Japan
推荐引用方式 GB/T 7714	Kanatani, Kumiko T.,Adachi, Yuichi,Hamazaki, Kei,et al. Association between vitamin D deficiency and allergic symptom in pregnant women[J],2019,14(4).
APA	Kanatani, Kumiko T..,Adachi, Yuichi.,Hamazaki, Kei.,Onishi, Kazunari.,Go, Tohshin.,...&Masumoto, Toshio.(2019).Association between vitamin D deficiency and allergic symptom in pregnant women.PLOS ONE,14(4).
MLA	Kanatani, Kumiko T.,et al."Association between vitamin D deficiency and allergic symptom in pregnant women".PLOS ONE 14.4(2019).