干旱区生态环境知识资源中心(Arid): Sesquiterpenoids and mycotoxin swainsonine from the locoweed endophytic fungus Alternaria oxytropis

Arid

DOI	10.1016/j.phytochem.2019.05.012
	Sesquiterpenoids and mycotoxin swainsonine from the locoweed endophytic fungus Alternaria oxytropis
	Tan, Xiangmei 1,2; Zhang, Xiaoyan 1,2; Yu, Meng 1,2; Yu, Yongtao 3; Guo, Zhe 1,2; Gong, Ting 4,5; Niu, Shubin 6; Qin, Jianchun 7; Zou, Zhongmei 1,2; Ding, Gang 1,2
通讯作者	Ding, Gang
来源期刊	PHYTOCHEMISTRY
ISSN	0031-9422
出版年	2019
卷号	164 页码:154-161
英文摘要	Oxytropiols A-J, ten undescribed guaiane-type sesquiterpenoids, and the mycotoxin swainsonine (SW) were isolated from the locoweed endophytic fungus Alternaria oxytropis. The chemical structures of these sesquiterpenoids were elucidated on the basis of HR-ESI-MS and NMR data including H-1, C-13, HSQC, H-1 -H-1 COSY, HMBC, and NOESY spectra, and the absolute configurations of these compounds were determined using a modified Mosher's method and X-ray diffraction spectroscopy. A possible biosynthetic pathway of these guaiane-type sesquiterpenoids is discussed, and proposed that post-modification oxidative enzymes might form these highly polyhydroxylated structures. Compound 1 displayed biological effects on the root growth of Arabidopsis thaliana, and SW displayed cytotoxicity against A549 and HeLa cancer cell lines.
英文关键词	Desert plant Oxytropis glabra (Leguminosae) Endophytic fungus Alternaria oxytropis Oxytropiols Swainsonine Bioactivities
类型	Article
语种	英语
国家	Peoples R China
收录类别	SCI-E
WOS记录号	WOS:000475996800018
WOS关键词	ALKALOID SWAINSONINE ; UNDIFILUM ; BIOSYNTHESIS
WOS类目	Biochemistry & Molecular Biology ; Plant Sciences
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217972
作者单位	1.Chinese Acad Med Sci, Key Lab Bioact Subst & Resources Utilizat Chinese, Inst Med Plant Dev, Minist Educ, Beijing 100193, Peoples R China; 2.Peking Union Med Coll, Beijing 100193, Peoples R China; 3.Ningxia Univ, Sch Agr, Yinchuan 750021, Peoples R China; 4.Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China; 5.Peking Union Med Coll, Beijing 100050, Peoples R China; 6.Beijing City Univ, Sch Biol Med, Beijing 450046, Peoples R China; 7.Jilin Univ, Coll Plant Sci, Changchun 130062, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Tan, Xiangmei,Zhang, Xiaoyan,Yu, Meng,et al. Sesquiterpenoids and mycotoxin swainsonine from the locoweed endophytic fungus Alternaria oxytropis[J],2019,164:154-161.
APA	Tan, Xiangmei.,Zhang, Xiaoyan.,Yu, Meng.,Yu, Yongtao.,Guo, Zhe.,...&Ding, Gang.(2019).Sesquiterpenoids and mycotoxin swainsonine from the locoweed endophytic fungus Alternaria oxytropis.PHYTOCHEMISTRY,164,154-161.
MLA	Tan, Xiangmei,et al."Sesquiterpenoids and mycotoxin swainsonine from the locoweed endophytic fungus Alternaria oxytropis".PHYTOCHEMISTRY 164(2019):154-161.