干旱区生态环境知识资源中心(Arid): Comparative and evolutionary analysis of the reptilian hedgehog gene family (Shh, Dhh, and Ihh)

Arid

DOI	10.7717/peerj.7613
	Comparative and evolutionary analysis of the reptilian hedgehog gene family (Shh, Dhh, and Ihh)
	Xia, Tian 1; Zhang, Honghai 1; Zhang, Lei 1; Yang, Xiufeng 1; Sun, Guolei 1; Chen, Jun 2; Xu, Dajie 1; Zhao, Chao 1
通讯作者	Zhang, Honghai
来源期刊	PEERJ
ISSN	2167-8359
出版年	2019
卷号	7
英文摘要	The hedgehog signaling pathway plays a vital role in human and animal patterning and cell proliferation during the developmental process. The hedgehog gene family of vertebrate species includes three genes, Shh, Dhh, and Ihh, which possess different functions and expression patterns. Despite the importance of hedgehog genes, genomic evidence of this gene family in reptiles is lacking. In this study, the available genomes of a number of representative reptile species were explored by utilizing adaptive evolutionary analysis methods to characterize the evolutionary patterns of the hedgehog gene family. Altogether, 33 sonic hedgehog (Shh), 25 desert hedgehog (Dhh), and 20 Indian hedgehog (Ihh) genes were obtained from reptiles, and six avian and five mammalian sequences were added to the analysis. The phylogenetic maximum likelihood (ML) tree of the Shh, Dhh, and Ihh genes revealed a similar topology, which is approximately consistent with the traditional taxonomic group. No shared positive selection site was identified by the PAML site model or the three methods in the Data Monkey Server. Branch model and Clade model C analyses revealed that the Dhh and Ihh genes experienced different evolutionary forces in reptiles and other vertebrates, while the Shh gene was not significantly different in terms of selection pressure. The different evolutionary rates of the Dhh and Ihh genes suggest that these genes may be potential contributors to the discrepant sperm and body development of different clades. The different adaptive evolutionary history of the Shh, Dhh, and Ihh genes among reptiles may be due to their different functions in regulating cellular events of development from the embryonic stages to adulthood. Overall, this study has provided meaningful information regarding the evolution of the hedgehog gene family in reptiles and a theoretical foundation for further analyses on the functional and molecular mechanisms that have shaped the reptilian hedgehog genes.
英文关键词	Reptiles Hedgehog gene family Phylogenetic analysis PAML
类型	Article
语种	英语
国家	Peoples R China
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000483309400010
WOS关键词	SONIC-HEDGEHOG ; MOLECULAR EVOLUTION ; SELECTION ; PRESSURE ; INSIGHTS ; POLARITY ; HH
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217917
作者单位	1.Qufu Normal Univ, Coll Life Sci, Qufu, Shandong, Peoples R China; 2.Ocean Univ Qingdao, Coll Marine Life Sci, Qingdao, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Xia, Tian,Zhang, Honghai,Zhang, Lei,et al. Comparative and evolutionary analysis of the reptilian hedgehog gene family (Shh, Dhh, and Ihh)[J],2019,7.
APA	Xia, Tian.,Zhang, Honghai.,Zhang, Lei.,Yang, Xiufeng.,Sun, Guolei.,...&Zhao, Chao.(2019).Comparative and evolutionary analysis of the reptilian hedgehog gene family (Shh, Dhh, and Ihh).PEERJ,7.
MLA	Xia, Tian,et al."Comparative and evolutionary analysis of the reptilian hedgehog gene family (Shh, Dhh, and Ihh)".PEERJ 7(2019).