干旱区生态环境知识资源中心(Arid): Prognosis predictive value of the Oxford Acute Severity of Illness Score for sepsis: a retrospective cohort study

Arid

DOI	10.7717/peerj.7083
	Prognosis predictive value of the Oxford Acute Severity of Illness Score for sepsis: a retrospective cohort study
	Chen, Qingui; Zhang, Lishan; Ge, Shanhui; He, Wanmei; Zeng, Mian
通讯作者	Zeng, Mian
来源期刊	PEERJ
ISSN	2167-8359
出版年	2019
卷号	7
英文摘要	Background: The Oxford Acute Severity of Illness Score (OASIS) has shown fair prognosis predictive value in critically ill patients, but its predictive value has not been assessed in septic patients. Objective: The aim of this study was to evaluate the performance of the OASIS for the assessment of mortality in septic patients, especially when compared with the Sepsis-related Organ Failure Assessment (SOFA) score. Methods: A retrospective cohort study was conducted using data from a public database and septic patients were identified using the Sepsis-3 criteria. The primary outcome was hospital mortality. Data were mainly analyzed using multivariable logistic regression and receiver operating characteristic (ROC) curves. Sensitive analyses were performed in patients with an ICD-9-CM code for sepsis and ROC curves analyses were also conducted in septic patients stratified by the Simplified Acute Physiology Score (SAPS) II as subgroup analyses. Results: A total of 10,305 septic patients were included. The OASIS was found to be significantly associated with hospital mortality (odds ratio 1.07 per one-point increase, 95% confidence interval [1.06-1.08]), while ROC curves analyses showed the discriminatory power of the OASIS for hospital mortality was statistically significantly lower than that of the SOFA score (area under the ROC curve: 0.652 vs 0.682, p < 0.001). Results of sensitive analyses were consistent, but the significant difference existed only when the SAPS II was higher than 50 according to results of the subgroup analyses. Conclusions: The OASIS might serve as an initial predictor of clinical outcomes for septic patients, but one should be circumspect when it is applied to severer patients.
英文关键词	Sepsis Severity of illness index Critical care outcomes Mortality
类型	Article
语种	英语
国家	Peoples R China
开放获取类型	Green Submitted, gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000470816000006
WOS关键词	INTERNATIONAL CONSENSUS DEFINITIONS ; SOFA SCORE ; ACUTE PHYSIOLOGY ; MULTICENTER ; CRITERIA
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217908
作者单位	Sun Yat Sen Univ, Dept Med Intens Care Unit, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Chen, Qingui,Zhang, Lishan,Ge, Shanhui,et al. Prognosis predictive value of the Oxford Acute Severity of Illness Score for sepsis: a retrospective cohort study[J],2019,7.
APA	Chen, Qingui,Zhang, Lishan,Ge, Shanhui,He, Wanmei,&Zeng, Mian.(2019).Prognosis predictive value of the Oxford Acute Severity of Illness Score for sepsis: a retrospective cohort study.PEERJ,7.
MLA	Chen, Qingui,et al."Prognosis predictive value of the Oxford Acute Severity of Illness Score for sepsis: a retrospective cohort study".PEERJ 7(2019).