干旱区生态环境知识资源中心(Arid): Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2

Arid

DOI	10.1038/s41467-019-11894-3
	Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2
	Khetchoumian, Konstantin 1; Balsalobre, Aurelio 1; Mayran, Alexandre 1; Christian, Helen 2,3,4; Chenard, Valerie 5; St-Pierre, Julie 5; Drouin, Jacques 1,5
通讯作者	Khetchoumian, Konstantin ; Drouin, Jacques
来源期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2019
卷号	10
英文摘要	Translation is a basic cellular process and its capacity is adapted to cell function. In particular, secretory cells achieve high protein synthesis levels without triggering the protein stress response. It is unknown how and when translation capacity is increased during differentiation. Here, we show that the transcription factor Creb3l2 is a scaling factor for translation capacity in pituitary secretory cells and that it directly binds -75% of regulatory and effector genes for translation. In parallel with this cell-autonomous mechanism, implementation of the physiological UPR pathway prevents triggering the protein stress response. Knockout mice for Tpit, a pituitary differentiation factor, show that Creb3l2 expression and its downstream regulatory network are dependent on Tpit. Further, Creb3l2 acts by direct targeting of translation effector genes in parallel with signaling pathways that otherwise regulate protein synthesis. Expression of Creb3l2 may be a useful means to enhance production of therapeutic proteins.
类型	Article
语种	英语
国家	Canada ; England
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000483711600001
WOS关键词	INCREASES PROTEIN-SYNTHESIS ; MITOCHONDRIAL BIOGENESIS ; GENE ONTOLOGY ; GOLGI STRESS ; OASIS FAMILY ; PROMOTES ; XBP1 ; COACTIVATOR ; EXPRESSION ; TPIT
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
来源机构	University of Oxford
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217747
作者单位	1.IRCM, Lab Genet Mol, Montreal, PQ H2W 1R7, Canada; 2.Univ Oxford, Dept Physiol, Oxford OX2 6HS, England; 3.Univ Oxford, Dept Anat, Oxford OX2 6HS, England; 4.Univ Oxford, Dept Genet, Oxford OX2 6HS, England; 5.McGill Univ, Rosalind & Morris Goodman Res Ctr, Dept Biochem, Montreal, PQ H3A 1A3, Canada
推荐引用方式 GB/T 7714	Khetchoumian, Konstantin,Balsalobre, Aurelio,Mayran, Alexandre,et al. Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2[J]. University of Oxford,2019,10.
APA	Khetchoumian, Konstantin.,Balsalobre, Aurelio.,Mayran, Alexandre.,Christian, Helen.,Chenard, Valerie.,...&Drouin, Jacques.(2019).Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2.NATURE COMMUNICATIONS,10.
MLA	Khetchoumian, Konstantin,et al."Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2".NATURE COMMUNICATIONS 10(2019).