干旱区生态环境知识资源中心(Arid): alpha-Pyrone derivatives with cyto-protective activity from two Takla Makan desert soil derived actinomycete Nocardiopsis strains recovered in seawater based medium

Arid

DOI	10.1080/14786419.2018.1455046
	alpha-Pyrone derivatives with cyto-protective activity from two Takla Makan desert soil derived actinomycete Nocardiopsis strains recovered in seawater based medium
	Zhao, Tingting 1; Chang, Yimin 1; Zhu, Tianjiao 1,2; Li, Jing 3; Gu, Qianqun 1; Li, Dehai 1,2; Che, Qian 1,2; Zhang, Guojian 1,2
通讯作者	Che, Qian ; Zhang, Guojian
来源期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6419
EISSN	1478-6427
出版年	2019
卷号	33 期号:17 页码:2498-2506
英文摘要	In this paper, we described the discovery of two Nocardiopsis strains HDN154-146 and HDN154-168 from Takla Makan desert soil samples using seawater based medium. Chemical investigation of these two strains led to the discovery of eight new alpha-pyrone derivatives named nocahypyrones A-H (1-8), together with one known analogue germicidin G (9). The structures of these compounds, including absolute configurations, were elucidated by extensive NMR, MS, and CD analyses. Compounds 1-9 were tested for their cyto-protective activities and for the first time we found alpha-pyrones 5 and 8 exhibited capabilities to induce expression of phase II detoxifying enzymes. [GRAPHICS] .
英文关键词	Nocardiopsis alpha-Pyrones cytoprotective phase II detoxifying enzymes
类型	Article
语种	英语
国家	Peoples R China
收录类别	SCI-E
WOS记录号	WOS:000473513100010
WOS关键词	FUSALANIPYRONE ; METABOLITES ; INHIBITORS ; TOXICITY ; ACID
WOS类目	Chemistry, Applied ; Chemistry, Medicinal
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217723
作者单位	1.Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao, Shandong, Peoples R China; 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Shandong, Peoples R China; 3.Ocean Univ China, Coll Marine Life Sci, Qingdao, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Tingting,Chang, Yimin,Zhu, Tianjiao,et al. alpha-Pyrone derivatives with cyto-protective activity from two Takla Makan desert soil derived actinomycete Nocardiopsis strains recovered in seawater based medium[J],2019,33(17):2498-2506.
APA	Zhao, Tingting.,Chang, Yimin.,Zhu, Tianjiao.,Li, Jing.,Gu, Qianqun.,...&Zhang, Guojian.(2019).alpha-Pyrone derivatives with cyto-protective activity from two Takla Makan desert soil derived actinomycete Nocardiopsis strains recovered in seawater based medium.NATURAL PRODUCT RESEARCH,33(17),2498-2506.
MLA	Zhao, Tingting,et al."alpha-Pyrone derivatives with cyto-protective activity from two Takla Makan desert soil derived actinomycete Nocardiopsis strains recovered in seawater based medium".NATURAL PRODUCT RESEARCH 33.17(2019):2498-2506.