干旱区生态环境知识资源中心(Arid): Chaetomadrasins A and B, Two New Cytotoxic Cytochalasans from Desert Soil-Derived Fungus Chaetomium madrasense 375

Arid

DOI	10.3390/molecules24183240
	Chaetomadrasins A and B, Two New Cytotoxic Cytochalasans from Desert Soil-Derived Fungus Chaetomium madrasense 375
	Guo, Qing-Feng 1; Yin, Zhen-Hua 1; Zhang, Juan-Juan 1; Kang, Wen-Yi 1; Wang, Xue-Wei 2; Ding, Gang 3,4; Chen, Lin1
通讯作者	Ding, Gang ; Chen, Lin
来源期刊	MOLECULES
EISSN	1420-3049
出版年	2019
卷号	24 期号:18
英文摘要	Two new cytochalasans, Chaetomadrasins A (1) and B (2), along with six known analogues (3-8), were isolated from the solid-state fermented culture of desert soil-derived Chaetomium madrasense 375. Their structures were clarified by comprehensive spectroscopic analyses, and the absolute configurations of Compounds 1 and 2 were confirmed by electronic circular dichroism (ECD) and calculated ECD. For the first time, Chaetomadrasins A (1), which belongs to the chaetoglobosin family, is characterized by the presence of all oxygen atoms in the form of Carbonyl. Chaetomadrasin B (2) represents the first example of chaetoglobosin type cytochalasan characterized by a hydroxy unit and carbonyl group fused to the indole ring. Compounds 1 and 2 displayed moderate cytotoxicity against HepG2 human hepatocellular carcinoma cells.
英文关键词	Chaetomium madrasense cytochalasans cytotoxicity fungal alkaloids
类型	Article
语种	英语
国家	Peoples R China
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000488830500032
WOS关键词	ENDOPHYTIC FUNGUS ; CHAETOGLOBOSIN-F ; RING-SYSTEM ; GLOBOSUM ; ALKALOIDS ; CELLS
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217684
作者单位	1.Huanghe Sci & Technol Coll, Zhengzhou Key Lab Synthet Biol Nat Prod, Henan Joint Int Res Lab Drug Discovery Small Mol, Zhengzhou 450063, Henan, Peoples R China; 2.Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China; 3.Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China; 4.Union Med Coll, Beijing 100193, Peoples R China
推荐引用方式 GB/T 7714	Guo, Qing-Feng,Yin, Zhen-Hua,Zhang, Juan-Juan,et al. Chaetomadrasins A and B, Two New Cytotoxic Cytochalasans from Desert Soil-Derived Fungus Chaetomium madrasense 375[J],2019,24(18).
APA	Guo, Qing-Feng.,Yin, Zhen-Hua.,Zhang, Juan-Juan.,Kang, Wen-Yi.,Wang, Xue-Wei.,...&Chen, Lin.(2019).Chaetomadrasins A and B, Two New Cytotoxic Cytochalasans from Desert Soil-Derived Fungus Chaetomium madrasense 375.MOLECULES,24(18).
MLA	Guo, Qing-Feng,et al."Chaetomadrasins A and B, Two New Cytotoxic Cytochalasans from Desert Soil-Derived Fungus Chaetomium madrasense 375".MOLECULES 24.18(2019).