干旱区生态环境知识资源中心(Arid): Echinacoside Isolated from Cistanche tubulosa Putatively Stimulates Growth Hormone Secretion via Activation of the Ghrelin Receptor

Arid

DOI	10.3390/molecules24040720
	Echinacoside Isolated from Cistanche tubulosa Putatively Stimulates Growth Hormone Secretion via Activation of the Ghrelin Receptor
	Wu, Chieh-Ju 1; Chien, Mei-Yin 2; Lin, Nan-Hei 1; Lin, Yi-Chiao 1; Chen, Wen-Ying 3; Chen, Chao-Hsiang 2,4; Tzen, Jason T. C.1
通讯作者	Chen, Chao-Hsiang ; Tzen, Jason T. C.
来源期刊	MOLECULES
EISSN	1420-3049
出版年	2019
卷号	24 期号:4
英文摘要	Cistanche species, the ginseng of the desert, has been recorded to possess many biological activities in traditional Chinese pharmacopoeia and has been used as an anti-aging medicine. Three phenylethanoid glycosidesechinacoside, tubuloside A, and acteosidewere detected in the water extract of Cistanche tubulosa (Schenk) R. Wight and the major constituent, echinacoside, was further purified. Echinacoside of a concentration higher than 10(-6) M displayed significant activity to stimulate growth hormone secretion of rat pituitary cells. Similar to growth hormone-releasing hormone-6, a synthetic analog of ghrelin, the stimulation of growth hormone secretion by echinacoside was inhibited by [D-Arg(1), D-Phe(5), D-Trp(7,9), Leu(11)]-substance P, an inverse agonist of the ghrelin receptor. Molecular modeling showed that all the three phenylethanoid glycosides adequately interacted with the binding pocket of the ghrelin receptor, and echinacoside displayed a slightly better interaction with the receptor than tubuloside A and acteoside. The results suggest that phenylethanoid glycosides, particularly echinacoside, are active constituents putatively responsible for the anti-aging effects of C. tubulosa and may be considered to develop as non-peptidyl analogues of ghrelin.
英文关键词	cistanche tubulosa echinacoside ghrelin growth hormone secretion phenylethanoid glycosides
类型	Article
语种	英语
国家	Taiwan
开放获取类型	Green Published, gold, Green Submitted
收录类别	SCI-E
WOS记录号	WOS:000460805900066
WOS关键词	IDENTIFICATION ; RAT ; TEAGHRELINS ; AGONISTS ; EXTRACT ; PEPTIDE ; MODEL ; MA
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217680
作者单位	1.Natl Chung Hsing Univ, Grad Inst Biotechnol, Taichung 402, Taiwan; 2.Ko Da Pharmaceut Co Ltd, Taoyuan 324, Taiwan; 3.Natl Chung Hsing Univ, Dept Vet Med, Taichung 402, Taiwan; 4.Taipei Med Univ, Grad Inst Pharmacognosy, Taipei 110, Taiwan
推荐引用方式 GB/T 7714	Wu, Chieh-Ju,Chien, Mei-Yin,Lin, Nan-Hei,et al. Echinacoside Isolated from Cistanche tubulosa Putatively Stimulates Growth Hormone Secretion via Activation of the Ghrelin Receptor[J],2019,24(4).
APA	Wu, Chieh-Ju.,Chien, Mei-Yin.,Lin, Nan-Hei.,Lin, Yi-Chiao.,Chen, Wen-Ying.,...&Tzen, Jason T. C..(2019).Echinacoside Isolated from Cistanche tubulosa Putatively Stimulates Growth Hormone Secretion via Activation of the Ghrelin Receptor.MOLECULES,24(4).
MLA	Wu, Chieh-Ju,et al."Echinacoside Isolated from Cistanche tubulosa Putatively Stimulates Growth Hormone Secretion via Activation of the Ghrelin Receptor".MOLECULES 24.4(2019).