干旱区生态环境知识资源中心(Arid): Analysis of 27 beta-Blockers and Metabolites in Milk Powder by High Performance Liquid Chromatography Coupled to Quadrupole Orbitrap High-Resolution Mass Spectrometry

Arid

DOI	10.3390/molecules24040820
	Analysis of 27 beta-Blockers and Metabolites in Milk Powder by High Performance Liquid Chromatography Coupled to Quadrupole Orbitrap High-Resolution Mass Spectrometry
	Cheng, Jian-Qiao 1,2; Liu, Tong 1; Nie, Xue-Mei 1; Chen, Feng-Ming 1; Wang, Chuan-Sheng 2; Zhang, Feng 1
通讯作者	Zhang, Feng
来源期刊	MOLECULES
EISSN	1420-3049
出版年	2019
卷号	24 期号:4
英文摘要	This paper presents an application of high performance liquid chromatography coupled with quadrupole orbitrap high-resolution mass spectrometry (HPLC-Q-Orbitrap HRMS) for the analysis of 27 -blockers and metabolites in milk powder. Homogenized milk power samples were extracted by acetonitrile and purified by using Oasis PRiME HLB solid-phase extraction cartridges. The Ascentis((R)) C8 chromatographic column was used to separate the analytes. The quantification was achieved by using matrix-matched standard calibration curves with carazolol-d(7) and propranolol-d(7) as the internal standards. The results show an exceptional linear relationship with the concentrations of analytes over wide concentration ranges (0.5-500 g kg(-1)) as all the fitting coefficients of determination r(2) are > 0.995. All the limits of detection (LODs) and quantitation (LOQs) values were within the respective range of 0.2-1.5 g kg(-1) and 0.5-5.0 g kg(-1). Overall average recoveries were able to reach 66.1-100.4% with the intra- and inter-day variability under 10%. This method has been successfully applied to the screening of -blockers and metabolites in commercial milk powders. At the same time, the corresponding characteristic fragmentation behavior of the 27 compounds was explored. The characteristic product ions were determined and applied to the actual samples screening.
英文关键词	beta-blockers metabolites milk powder Q-Orbitrap
类型	Article
语种	英语
国家	Peoples R China
开放获取类型	gold, Green Submitted, Green Published
收录类别	SCI-E
WOS记录号	WOS:000460805900166
WOS关键词	SCREENING METHOD ; HUMAN URINE ; MS METHOD ; EXTRACTION ; SEDATIVES ; GC ; BETA(2)-AGONISTS ; TRANQUILIZERS ; PORCINE ; TISSUES
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217678
作者单位	1.Chinese Acad Inspect & Quarantine, Inst Food Safety, Beijing 100176, Peoples R China; 2.Shenyang Univ Chem Technol, Coll Appl Chem, Shenyang 110142, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Jian-Qiao,Liu, Tong,Nie, Xue-Mei,et al. Analysis of 27 beta-Blockers and Metabolites in Milk Powder by High Performance Liquid Chromatography Coupled to Quadrupole Orbitrap High-Resolution Mass Spectrometry[J],2019,24(4).
APA	Cheng, Jian-Qiao,Liu, Tong,Nie, Xue-Mei,Chen, Feng-Ming,Wang, Chuan-Sheng,&Zhang, Feng.(2019).Analysis of 27 beta-Blockers and Metabolites in Milk Powder by High Performance Liquid Chromatography Coupled to Quadrupole Orbitrap High-Resolution Mass Spectrometry.MOLECULES,24(4).
MLA	Cheng, Jian-Qiao,et al."Analysis of 27 beta-Blockers and Metabolites in Milk Powder by High Performance Liquid Chromatography Coupled to Quadrupole Orbitrap High-Resolution Mass Spectrometry".MOLECULES 24.4(2019).