干旱区生态环境知识资源中心(Arid): Phytochemical Characterization and Evaluation of the Antimicrobial, Antiproliferative and Pro-Apoptotic Potential of Ephedra alata Decne. Hydroalcoholic Extract against the MCF-7 Breast Cancer Cell Line

Arid

DOI	10.3390/molecules24010013
	Phytochemical Characterization and Evaluation of the Antimicrobial, Antiproliferative and Pro-Apoptotic Potential of Ephedra alata Decne. Hydroalcoholic Extract against the MCF-7 Breast Cancer Cell Line
	Danciu, Corina 1; Muntean, Delia 2; Alexa, Ersilia 3; Farcas, Claudia 4; Oprean, Camelia 5,6; Zupko, Istvan 7; Bor, Andrea 7; Minda, Daliana 1; Proks, Maria 8; Buda, Valentina 8; Hancianu, Monica 9; Cioanca, Oana 9; Soica, Codruta 10; Popescu, Sofia 3; Dehelean, Cristina Adriana 11
通讯作者	Minda, Daliana ; Buda, Valentina
来源期刊	MOLECULES
EISSN	1420-3049
出版年	2019
卷号	24 期号:1
英文摘要	Ephedra alata Decne. belongs to the Ephedraceae family. It is a species of Ephedra that grows mostly in the desert. Today, the main importance of Ephedra species in the medical field is due to the presence of the alkaloids derived from phenyl-alanine, which act on the sympathetic nervous system as a sympathomimetic. The aim of this study was to conduct a phytochemical characterization of the hydroalcoholic extract of the aerial part of Ephedra alata Decne., which is indigenous to Tunis, that involves the total phenolic content, individual phenolic content, and antioxidant activity as well as a biological screening for the evaluation of the antimicrobial, antifungal, antiproliferative, pro-apoptotic, and cytotoxic potential against the MCF-7 breast cancer cell line. The results show that the hydroalcoholic extract contains polyphenolic phytocompounds (156.226 +/- 0.5 mgGAE/g extract) and elicits antioxidant activity (7453.18 +/- 2.5 mol Trolox/g extract). The extract acted as a bacteriostatic agent against all tested bacterial strains, but was bactericidal only against the Gram-positive cocci and Candida spp. In the set experimental parameters, the extract presents antiproliferative, pro-apoptotic, and cytotoxic potential against the MCF-7 human breast cancer cell line.
英文关键词	Ephedra alata Decne polyphenols antioxidant bacteria fungi MCF-7 human breast cancer cell line
类型	Article
语种	英语
国家	Romania ; Hungary
开放获取类型	Green Published, gold, Green Submitted, Green Accepted
收录类别	SCI-E
WOS记录号	WOS:000457150200013
WOS关键词	IN-VITRO ; CHEMICAL-COMPOSITION ; BIOLOGICAL-ACTIVITY ; ANTIBACTERIAL ; ANTIOXIDANT ; ASSAY ; GROWTH
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217675
作者单位	1.Univ Med & Farm Timisoara, Dept Pharmacognosy, Eftimie Murgu Sq 2, Timisoara 300041, Romania; 2.Univ Med & Farm Timisoara, Dept Microbiol, Eftimie Murgu Sq 2, Timisoara 300041, Romania; 3.Banats Univ Agr Sci & Vet Med King Michael I Roma, Dept Food Control, Calea Aradului 119, Timisoara 300641, Romania; 4.Univ Med & Farm Timisoara, Dept Pharmaceut Phys, Eftimie Murgu Sq 2, Timisoara 300041, Romania; 5.Univ Med & Farm Timisoara, Dept Drug Anal Chem Environm & Food, Eftimie Murgu Sq 2, Timisoara 300041, Romania; 6.Cty Hosp Pius Branzeu, OncoGen Ctr, Blvd Liviu Rebreanu 156, Timisoara 300736, Romania; 7.Univ Szeged, Dept Pharmacodynam & Biopharm, Eotvos U 6, H-6720 Szeged, Hungary; 8.Univ Med & Farm Timisoara, Dept Pharmacol & Clin Pharm, Eftimie Murgu Sq 2, Timisoara 300041, Romania; 9.Grigore T Popa Univ Med & Pharm, Dept Pharmacognosy, Fac Pharm, Iasi 700115, Romania; 10.Univ Med & Farm Timisoara, Dept Pharmaceut Chem, Eftimie Murgu Sq 2, Timisoara 300041, Romania; 11.Univ Med & Farm Timisoara, Dept Toxicol, Eftimie Murgu Sq 2, Timisoara 300041, Romania
推荐引用方式 GB/T 7714	Danciu, Corina,Muntean, Delia,Alexa, Ersilia,et al. Phytochemical Characterization and Evaluation of the Antimicrobial, Antiproliferative and Pro-Apoptotic Potential of Ephedra alata Decne. Hydroalcoholic Extract against the MCF-7 Breast Cancer Cell Line[J],2019,24(1).
APA	Danciu, Corina.,Muntean, Delia.,Alexa, Ersilia.,Farcas, Claudia.,Oprean, Camelia.,...&Dehelean, Cristina Adriana.(2019).Phytochemical Characterization and Evaluation of the Antimicrobial, Antiproliferative and Pro-Apoptotic Potential of Ephedra alata Decne. Hydroalcoholic Extract against the MCF-7 Breast Cancer Cell Line.MOLECULES,24(1).
MLA	Danciu, Corina,et al."Phytochemical Characterization and Evaluation of the Antimicrobial, Antiproliferative and Pro-Apoptotic Potential of Ephedra alata Decne. Hydroalcoholic Extract against the MCF-7 Breast Cancer Cell Line".MOLECULES 24.1(2019).