干旱区生态环境知识资源中心(Arid): The Bear Giant-Skipper genome suggests genetic adaptations to living inside yucca roots

Arid

DOI	10.1007/s00438-018-1494-6
	The Bear Giant-Skipper genome suggests genetic adaptations to living inside yucca roots
	Cong, Qian 2,3; Li, Wenlin 2,3; Borek, Dominika 2,3; Otwinowski, Zbyszek 2,3; Grishin, Nick V.1,2,3
通讯作者	Grishin, Nick V.
来源期刊	MOLECULAR GENETICS AND GENOMICS
ISSN	1617-4615
EISSN	1617-4623
出版年	2019
卷号	294 期号:1 页码:211-226
英文摘要	Giant-Skippers (Megathymini) are unusual thick-bodied, moth-like butterflies whose caterpillars feed inside Yucca roots and Agave leaves. Giant-Skippers are attributed to the subfamily Hesperiinae and they are endemic to southern and mostly desert regions of the North American continent. To shed light on the genotypic determinants of their unusual phenotypic traits, we sequenced and annotated a draft genome of the largest Giant-Skipper species, the Bear (Megathymus ursus violae). The Bear skipper genome is the least heterozygous among sequenced Lepidoptera genomes, possibly due to much smaller population size and extensive inbreeding. Their lower heterozygosity helped us to obtain a high-quality genome with an N50 of 4.2 Mbp. The similar to 430Mb genome encodes about 14000 proteins. Phylogenetic analysis supports placement of Giant-Skippers with Grass-Skippers (Hesperiinae). We find that proteins involved in odorant and taste sensing as well as in oxidative reactions have diverged significantly in Megathymus as compared to Lerema, another Grass-Skipper. In addition, the Giant-Skipper has lost several odorant and gustatory receptors and possesses many fewer (1/3-1/2 of other skippers) anti-oxidative enzymes. Such differences may be related to the unusual life style of Giant-Skippers: they do not feed as adults, and their caterpillars feed inside Yuccas and Agaves, which provide a source of antioxidants such as polyphenols.
英文关键词	Skipper butterflies Root borers Comparative genomics Antioxidants
类型	Article
语种	英语
国家	USA
开放获取类型	Green Accepted
收录类别	SCI-E
WOS记录号	WOS:000457456800018
WOS关键词	HIGHLY HETEROZYGOUS GENOMES ; IDENTIFICATION ; LEPIDOPTERA ; CLASSIFICATION ; BUTTERFLIES ; ANNOTATION ; SOFTWARE ; PIPELINE ; INSIGHTS ; PLATFORM
WOS类目	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS研究方向	Biochemistry & Molecular Biology ; Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217657
作者单位	1.Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, 5323 Harry Hines Blvd, Dallas, TX 75390 USA; 2.Univ Texas Southwestern Med Ctr Dallas, Dept Biophys, 5323 Harry Hines Blvd, Dallas, TX 75390 USA; 3.Univ Texas Southwestern Med Ctr Dallas, Dept Biochem, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
推荐引用方式 GB/T 7714	Cong, Qian,Li, Wenlin,Borek, Dominika,et al. The Bear Giant-Skipper genome suggests genetic adaptations to living inside yucca roots[J],2019,294(1):211-226.
APA	Cong, Qian,Li, Wenlin,Borek, Dominika,Otwinowski, Zbyszek,&Grishin, Nick V..(2019).The Bear Giant-Skipper genome suggests genetic adaptations to living inside yucca roots.MOLECULAR GENETICS AND GENOMICS,294(1),211-226.
MLA	Cong, Qian,et al."The Bear Giant-Skipper genome suggests genetic adaptations to living inside yucca roots".MOLECULAR GENETICS AND GENOMICS 294.1(2019):211-226.