Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.molcel.2019.08.026 |
Lysine Methylation Regulators Moonlighting outside the Epigenome | |
Cornett, Evan M.1; Ferry, Laure2; Defossez, Pierre-Antoine2; Rothbart, Scott B.3 | |
通讯作者 | Cornett, Evan M. ; Rothbart, Scott B. |
来源期刊 | MOLECULAR CELL
![]() |
ISSN | 1097-2765 |
EISSN | 1097-4164 |
出版年 | 2019 |
卷号 | 75期号:6页码:1092-1101 |
英文摘要 | Landmark discoveries made nearly two decades ago identified known transcriptional regulators as histone lysine methyltransferases. Since then, the field of lysine methylation signaling has been dominated by studies of how this small chemical posttranslational modification regulates gene expression and other chromatin-based processes. However, recent advances in mass-spectrometry-based proteomics have revealed that histones are just a subset of the thousands of eukaryotic proteins marked by lysine methylation. As the writers, erasers, and readers of histone lysine methylation are emerging as a promising therapeutic target class for cancer and other diseases, a key challenge for the field is to define the full spectrum of activities for these proteins. Here we summarize recent discoveries implicating non-histonr lysine methylation as a major regulator of diverse cellular processes. We further discuss recent technological innovations that are enabling the expanded study of lysine methylation signaling. Collectively, these findings are shaping our understanding of the fundamental mechanisms of non-histone protein regulation through this dynamic arid multi-functional posttranslational modification. |
类型 | Review |
语种 | 英语 |
国家 | USA ; France |
收录类别 | SCI-E |
WOS记录号 | WOS:000486614200003 |
WOS关键词 | PROTEIN METHYLATION ; GLOBAL ANALYSIS ; HISTONE ; DNA ; CHROMATIN ; STRATEGY ; ALPHA ; TRIMETHYLATION ; IDENTIFICATION ; TRANSLATION |
WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/217646 |
作者单位 | 1.Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA; 2.Univ Paris, CNRS, Epigenet & Cell Fate, F-75013 Paris, France; 3.Van Andel Res Inst, Ctr Epigenet, Grand Rapids, MI 49503 USA |
推荐引用方式 GB/T 7714 | Cornett, Evan M.,Ferry, Laure,Defossez, Pierre-Antoine,et al. Lysine Methylation Regulators Moonlighting outside the Epigenome[J],2019,75(6):1092-1101. |
APA | Cornett, Evan M.,Ferry, Laure,Defossez, Pierre-Antoine,&Rothbart, Scott B..(2019).Lysine Methylation Regulators Moonlighting outside the Epigenome.MOLECULAR CELL,75(6),1092-1101. |
MLA | Cornett, Evan M.,et al."Lysine Methylation Regulators Moonlighting outside the Epigenome".MOLECULAR CELL 75.6(2019):1092-1101. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。